Aim The purpose of this study was to uncover insights into the mechanism of action of the 8‐
hydroxyquinoline derivatives PH151 and PH153. In addition, with the future perspective of …

Fungal infections have emerged as a current serious global public health problem. The main
problem involving these infections is the expansion of multidrug resistance. Therefore, the …

Clioquinol is an 8-hydroxyquinoline derivative that was widely used from the 1950s to 1970s
as an oral antiparasitic agent. In 1970, the oral forms were withdrawn from the market due to …

Aim The purpose of this study was to evaluate the antifungal activity and toxicological
parameters of 8‐hydroxyquinoline derivatives PH151 and PH153 using alternative animal …

The 8-hydroxyquinoline core is a privileged scaffold for drug design explored to afford novel
derivatives endowed with biological activity. Our research aimed at clarifying the antifungal …

The oral administration of clioquinol–a potent 8-hydroxyquinoline antimicrobial drug–was
forbidden due to suspicion of it being the cause of SMON (subacute myelo-optic …

In search of new environmentally friendly and effective antifungal agents, a series of 4‐
aminoquinolines bearing a 1, 3‐benzodioxole moiety were prepared and their structures …

Abstract Two series of 4-aryl-3-methyl-1, 2, 3, 4-tetrahydroquinoline derivatives were
efficiently synthesized according to a two-step synthesis and evaluated as potential …

We have identified two subseries of 2, 6-disubstituted quinolines, consisting of 6-amide and
6-urea derivatives, which are characterized by fungicidal activity against Candida albicans …

Fungal infections that affect humans and plants have increased significantly in recent
decades. However, these pathogens are still neglected when compared to other infectious …