[HTML][HTML] Heterogeneous responses in hepatocellular carcinoma: the achilles heel of immune checkpoint inhibitors

Z Lin, D Lu, X Wei, J Wang, X Xu - American journal of cancer …, 2020 - ncbi.nlm.nih.gov
Abstract Treatment of patients with hepatocellular carcinoma (HCC) remains a serious
challenge due to high heterogeneity and limited treatment options. In the past few decades …

Immune checkpoint inhibitors in HCC: Cellular, molecular and systemic data

U Harkus, M Wankell, P Palamuthusingam… - Seminars in Cancer …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related deaths in the
world, and for patients with advanced disease there are few therapeutic options available …

Immune checkpoint inhibitor resistance in hepatocellular carcinoma

Z Wang, Y Wang, P Gao, J Ding - Cancer Letters, 2023 - Elsevier
The application of immune checkpoint inhibitors (ICIs) has markedly enhanced the treatment
of hepatocellular carcinoma (HCC), and HCC patients who respond to ICIs have shown …

[HTML][HTML] Overcoming resistance to immune checkpoint inhibitors in hepatocellular carcinoma: challenges and opportunities

Q Xie, P Zhang, Y Wang, W Mei, C Zeng - Frontiers in Oncology, 2022 - frontiersin.org
Hepatocellular carcinoma is one of the leading causes of cancer mortality globally, and its
incidence is increasing. Immune checkpoint therapy has revolutionized the treatment of …

Immune checkpoint inhibitors as monotherapy or within a combinatorial strategy in advanced hepatocellular carcinoma

M Guardascione, G Toffoli - International Journal of Molecular Sciences, 2020 - mdpi.com
In advanced-stage hepatocellular carcinoma (HCC), systemic treatment represents the
standard therapy. Target therapy has marked a new era based on a greater knowledge of …

Prognostic biomarkers associated with immune checkpoint inhibitors in hepatocellular carcinoma

X Chen, L Kou, X Xie, S Su, J Li, Y Li - Immunology, 2024 - Wiley Online Library
The treatment of hepatocellular carcinoma (HCC), particularly advanced HCC, has been a
serious challenge. Immune checkpoint inhibitors (ICIs) are landmark drugs in the field of …

Advances in Immunotherapy for Hepatocellular Carcinoma (HCC)

F Bicer, C Kure, AA Ozluk, BF El-Rayes, M Akce - Current Oncology, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related
deaths in the world. More than half of patients with HCC present with advanced stage, and …

[HTML][HTML] Immune checkpoint inhibitors in hepatocellular carcinoma: current progresses and challenges

HT Liu, MJ Jiang, ZJ Deng, L Li, JL Huang… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common malignant tumor in the world
and its incidence is increasing in many countries. In recent years, with the deepening …

[HTML][HTML] The progress of research on immune checkpoint inhibitor resistance and reversal strategies for hepatocellular carcinoma

L Kou, X Xie, X Chen, B Li, J Li, Y Li - Cancer Immunology …, 2023 - Springer
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in humans,
which is prone to recurrence and metastasis and has a poor prognosis. The occurrence and …

[HTML][HTML] Immune checkpoint inhibitors in hepatocellular cancer: current understanding on mechanisms of resistance and biomarkers of response to treatment

AE Onuma, H Zhang, H Huang, TM Williams… - Gene …, 2020 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy worldwide
and a leading cause of death worldwide. Its incidence continues to increase in the US due to …