The formation of amyloid deposits in human tissues is a defining feature of more than 50
medical disorders, including Alzheimer's disease. Strong genetic and histological evidence …

Protein aggregation is a complex process resulting in the formation of heterogeneous
mixtures of aggregate populations that are closely linked to neurodegenerative conditions …

The generation of toxic oligomers during the aggregation of the amyloid-β (Aβ) peptide Aβ42
into amyloid fibrils and plaques has emerged as a central feature of the onset and …

Oligomeric species populated during the aggregation of the Aβ42 peptide have been
identified as potent cytotoxins linked to Alzheimer's disease, but the fundamental molecular …

The formation of amyloid β (1-42)(Aβ42) oligomers is considered to be a critical step in the
development of Alzheimer's disease (AD). However, the mechanism underlying this process …

Alzheimer's disease is a neurodegenerative disorder associated with the aberrant
aggregation of the amyloid-β peptide. Although increasing evidence implicates cholesterol …

Alzheimer's disease (AD) is linked with the self-association of the amyloid-β peptide (Aβ)
into oligomers and fibrils. The brain is a lipid rich environment for Aβ to assemble, while the …

The aggregation of the amyloid β (Aβ) peptide is one of the molecular hallmarks of
Alzheimer's disease (AD). Although Aβ deposits have mostly been observed extracellularly …

The molecular origins of Alzheimer's disease are associated with the aggregation of the
amyloid-β peptide (Aβ). This process is controlled by a complex cellular homeostasis …

Aggregation of the amyloid-β (Aβ) peptide is strongly correlated with Alzheimer's disease
(AD). Recent research has improved our understanding of the kinetics of amyloid fibril …