Right ventricle has normal myofilament function but shows perturbations in the expression of extracellular matrix genes in patients with tetralogy of fallot undergoing …

D Brayson, SJ Holohan, SC Bardswell… - Journal of the …, 2020 - Am Heart Assoc
Background Patients with repair of tetralogy of Fallot (rToF) who are approaching adulthood
often exhibit pulmonary valve regurgitation, leading to right ventricle (RV) dilatation and …

Right ventricular fibrosis is associated with cardiac remodelling after pulmonary valve replacement

K Yamamura, D Yuen, EJ Hickey, X He, RR Chaturvedi… - Heart, 2019 - heart.bmj.com
Objective The relationship between right ventricular (RV) fibrosis and right heart reverse
remodelling following pulmonary valve replacement (PVR) has not been well studied in …

Reversal of right ventricular remodeling after correction of pulmonary regurgitation in tetralogy of fallot

B Cools, CK Nagaraju, K Vandendriessche… - Basic to Translational …, 2023 - jacc.org
In the sheep model with pathophysiologic changes similar to patients with repaired TOF,
severe PR leads to fibrotic changes in the RV. Pulmonary valve replacement reverses these …

Right ventricular outflow tract enlargement prior to pulmonary valve replacement is associated with poorer structural and functional outcomes, in adults with repaired …

S O'Meagher, M Ganigara, P Munoz, DJ Tanous… - Heart, Lung and …, 2014 - Elsevier
Background Pulmonary valve replacement (PVR) is commonly performed late after
Tetralogy of Fallot (TOF) repair. We examined the effects of PVR on cardiac structure …

Biopsy-detected myocardial fibrosis predicts adverse cardiac events after pulmonary valve replacement in patients with repaired tetralogy of Fallot

J Yuan, Z Su, G Wang, K Yang, B Zhang… - Interdisciplinary …, 2023 - academic.oup.com
OBJECTIVES Risk factors associated with adverse cardiac events (cardiac AEs) after
pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot are …

[HTML][HTML] Right ventricular fibrosis after tetralogy of Fallot repair: can pulmonary valve replacement make a difference?

A Ishikita, MK Friedberg, RM Wald - Basic to Translational Science, 2023 - jacc.org
Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease.
Owing to advances in cardiovascular surgery, survival can now be expected into adulthood …

Right ventricular remodeling after pulmonary valve replacement: early gains, late losses

A Hallbergson, K Gauvreau, AJ Powell… - The Annals of thoracic …, 2015 - Elsevier
Background Although early results of pulmonary valve replacement (PVR) after tetralogy of
Fallot repair have been described, information about late postoperative ventricular size and …

“Pulmonary valve replacement diminishes the presence of restrictive physiology and reduces atrial volumes”: A prospective study in Tetralogy of Fallot patients

A Pijuan-Domenech, V Pineda, MA Castro… - International journal of …, 2014 - Elsevier
Pulmonary valve replacement (PVR) reduces right ventricular (RV) volumes in the setting of
long-term pulmonary regurgitation after Tetralogy of Fallot (ToF) repair; however, little is …

[HTML][HTML] Left ventricular strain derived from cardiac magnetic resonance can predict outcomes of pulmonary valve replacement in patients with repaired tetralogy of …

B Zhuang, S Yu, Z Feng, F He, Y Jiang… - Frontiers in …, 2022 - frontiersin.org
Purpose Several adults with repaired tetralogy of Fallot (rToF) undergo pulmonary valve
replacement (PVR) to reduce the right ventricular volume and retain right ventricular …

Immediate and midterm cardiac remodeling after surgical pulmonary valve replacement in adults with repaired tetralogy of Fallot: a prospective cardiovascular …

EL Heng, MA Gatzoulis, A Uebing, B Sethia… - Circulation, 2017 - Am Heart Assoc
Background: Pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot
provides symptomatic benefit and right ventricular (RV) volume reduction. However, data on …