Functionalized CARB Pharmacophore (FCP) approach to thio and unsaturated carbohydrate scaffolds with potential anticancer activity
ZJ Witczak, R Bielski, T Poplawski - 2020 - books.rsc.org
This brief review discusses some new developments in the functionalized carb
pharmacophore (FCP) concept introduced by us in 2014. While the examples concentrate …
pharmacophore (FCP) concept introduced by us in 2014. While the examples concentrate …
[PDF][PDF] Thio-glycomimetics with enhanced lipophilicity and their biological activity
ZJ Witczak, A Mauger, R Bielski, DE Mencer - Arkivoc, 2021 - arkat-usa.org
The thio-linked glycomimetics were prepared via a base-catalyzed, highly stereo-selective
Michael condensation of levoglucosenone with various sugar, heterocyclic and adamantane …
Michael condensation of levoglucosenone with various sugar, heterocyclic and adamantane …
[图书][B] Carbohydrates in Drug Discovery and Development: Synthesis and Application
VK Tiwari - 2020 - books.google.com
Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines
recent and notable developments in the synthesis, biology, therapeutic, and biomedical …
recent and notable developments in the synthesis, biology, therapeutic, and biomedical …
Thio-sugar motif of functional CARB-pharmacophore for antineoplastic activity. Part 2
ZJ Witczak, J Sarnik, A Czubatka, E Forma… - Bioorganic & Medicinal …, 2014 - Elsevier
Abstract Diverse functionalized representatives of (1-4)-S-thiodisaccharides, 6–9 were
synthesized and assessed for cytotoxicity and apoptosis against human cancer cell lines …
synthesized and assessed for cytotoxicity and apoptosis against human cancer cell lines …
Carbohydrate-based bioactive compounds for medicinal chemistry applications
In this article we review our work over the years on carbohydrates and carbohydrate
mimetics and their applications in medicinal chemistry. In the first part of the review …
mimetics and their applications in medicinal chemistry. In the first part of the review …
Development of Diverse Range of Biologically Relevant Carbohydrate‐Containing Molecules: Twenty Years of Our Journey
VK Tiwari - The Chemical Record, 2021 - Wiley Online Library
There is an increasing demand for significant amount of carbohydrate‐containing molecules
owing to their complete chemical, biological, and pharmacological investigations to better …
owing to their complete chemical, biological, and pharmacological investigations to better …
Carbohydrate-Based Molecules in Medicinal Chemistry
The therapeutic potential of carbohydrates has been well demonstrated by the number of
carbohydrate-based compounds, either synthetic, semi-synthetic or from natural sources for …
carbohydrate-based compounds, either synthetic, semi-synthetic or from natural sources for …
Carbohydrate-based therapeutics: a frontier in drug discovery and development
S Mishra, K Upadhaya, KB Mishra, AK Shukla… - Studies in Natural …, 2016 - Elsevier
Carbohydrates, one of the most abundant classes of biomolecules, are the structural
building blocks of genetic materials and vital source of energy. They are integral part of the …
building blocks of genetic materials and vital source of energy. They are integral part of the …
Carbohydrates: potential sweet tools against cancer
A Franconetti, Ó López… - Current Medicinal …, 2020 - ingentaconnect.com
Cancer, one of the most devastating degenerative diseases nowadays, is one of the main
targets in Medicinal Chemistry and Pharmaceutical industry. Due to the significant increase …
targets in Medicinal Chemistry and Pharmaceutical industry. Due to the significant increase …
Carbohydrate based potential chemotherapeutic agents: recent developments and their scope in future drug discovery
VK Tiwari, RC Mishra, A Sharma… - Mini Reviews in …, 2012 - ingentaconnect.com
In addition to being valuable source of energy, carbohydrates, one of the main dietary
components, are integral parts of the cell. As extra-& intracellular molecules they act as cell …
components, are integral parts of the cell. As extra-& intracellular molecules they act as cell …