Functionalized CARB Pharmacophore (FCP) approach to thio and unsaturated carbohydrate scaffolds with potential anticancer activity

ZJ Witczak, R Bielski, T Poplawski - 2020 - books.rsc.org
This brief review discusses some new developments in the functionalized carb
pharmacophore (FCP) concept introduced by us in 2014. While the examples concentrate …

[PDF][PDF] Thio-glycomimetics with enhanced lipophilicity and their biological activity

ZJ Witczak, A Mauger, R Bielski, DE Mencer - Arkivoc, 2021 - arkat-usa.org
The thio-linked glycomimetics were prepared via a base-catalyzed, highly stereo-selective
Michael condensation of levoglucosenone with various sugar, heterocyclic and adamantane …

[图书][B] Carbohydrates in Drug Discovery and Development: Synthesis and Application

VK Tiwari - 2020 - books.google.com
Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines
recent and notable developments in the synthesis, biology, therapeutic, and biomedical …

Thio-sugar motif of functional CARB-pharmacophore for antineoplastic activity. Part 2

ZJ Witczak, J Sarnik, A Czubatka, E Forma… - Bioorganic & Medicinal …, 2014 - Elsevier
Abstract Diverse functionalized representatives of (1-4)-S-thiodisaccharides, 6–9 were
synthesized and assessed for cytotoxicity and apoptosis against human cancer cell lines …

Carbohydrate-based bioactive compounds for medicinal chemistry applications

L Cipolla, F Peri - Mini reviews in medicinal chemistry, 2011 - ingentaconnect.com
In this article we review our work over the years on carbohydrates and carbohydrate
mimetics and their applications in medicinal chemistry. In the first part of the review …

Development of Diverse Range of Biologically Relevant Carbohydrate‐Containing Molecules: Twenty Years of Our Journey

VK Tiwari - The Chemical Record, 2021 - Wiley Online Library
There is an increasing demand for significant amount of carbohydrate‐containing molecules
owing to their complete chemical, biological, and pharmacological investigations to better …

Carbohydrate-Based Molecules in Medicinal Chemistry

NM Xavier, PR Andreana, I Carvalho… - Frontiers in …, 2021 - frontiersin.org
The therapeutic potential of carbohydrates has been well demonstrated by the number of
carbohydrate-based compounds, either synthetic, semi-synthetic or from natural sources for …

Carbohydrate-based therapeutics: a frontier in drug discovery and development

S Mishra, K Upadhaya, KB Mishra, AK Shukla… - Studies in Natural …, 2016 - Elsevier
Carbohydrates, one of the most abundant classes of biomolecules, are the structural
building blocks of genetic materials and vital source of energy. They are integral part of the …

Carbohydrates: potential sweet tools against cancer

A Franconetti, Ó López… - Current Medicinal …, 2020 - ingentaconnect.com
Cancer, one of the most devastating degenerative diseases nowadays, is one of the main
targets in Medicinal Chemistry and Pharmaceutical industry. Due to the significant increase …

Carbohydrate based potential chemotherapeutic agents: recent developments and their scope in future drug discovery

VK Tiwari, RC Mishra, A Sharma… - Mini Reviews in …, 2012 - ingentaconnect.com
In addition to being valuable source of energy, carbohydrates, one of the main dietary
components, are integral parts of the cell. As extra-& intracellular molecules they act as cell …