[图书][B] Rapid Genomic Change and Intraclonal Variation in the Bacterial Opportunistic Pathogens Haemophilus influenzae and Acinetobacter baumannii

KM Raible - 2020 - search.proquest.com
The immense genetic diversity observed within many human-associated bacterial species is
an important consideration when studying pathogenesis. The studies described here …

Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: adaptation and pathogenesis in the human airways

J Garmendia, P Martí-Lliteras, J Moleres, C Puig… - 2012 - digital.csic.es
The human respiratory tract contains a highly adapted microbiota including commensal and
opportunistic pathogens. Noncapsulated or nontypable Haemophilus influenzae (NTHi) is a …

[HTML][HTML] Virulence phenotypes of low-passage clinical isolates of Nontypeable Haemophilus influenzae assessed using the chinchilla laniger model of otitis media

FJ Buchinsky, ML Forbes, JD Hayes, K Shen, S Ezzo… - BMC microbiology, 2007 - Springer
Abstract Background The nontypeable Haemophilus influenzae (NTHi) are associated with
a spectrum of respiratory mucosal infections including: acute otitis media (AOM); chronic …

Haemophilus influenzae genome evolution during persistence in the human airways in chronic obstructive pulmonary disease

MM Pettigrew, CP Ahearn, JF Gent… - Proceedings of the …, 2018 - National Acad Sciences
Nontypeable Haemophilus influenzae (NTHi) exclusively colonize and infect humans and
are critical to the pathogenesis of chronic obstructive pulmonary disease (COPD). In vitro …

Comparative Genomic Analysis of Non-typeable Haemophilus Influenzae in Children with Acute and Chronic Pneumonia versus Healthy Controls

DM Zhang, W Wang, C Song, T Huang, H Chen, Z Liu… - medRxiv, 2024 - medrxiv.org
Non-typeable Hemophilus Influenzae (NTHi) is a common pathogen that can cause a range
of respiratory infections, including children pneumonia. However, NTHi can also be found in …

Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease …

R Kc, KWC Leong, NM Harkness… - Microbial …, 2020 - microbiologyresearch.org
Nontypeable Haemophilus influenzae (NTHi) colonizes human upper respiratory airways
and plays a key role in the course and pathogenesis of acute exacerbations of chronic …

Identification, Distribution, and Expression of Novel Genes in 10 Clinical Isolates of Nontypeable Haemophilus influenzae

K Shen, P Antalis, J Gladitz, S Sayeed… - Infection and …, 2005 - Am Soc Microbiol
We hypothesize that Haemophilus influenzae, as a species, possesses a much greater
number of genes than that found in any single H. influenzae genome. This supragenome is …

Genome sequencing of disease and carriage isolates of nontypeable Haemophilus influenzae identifies discrete population structure

M De Chiara, D Hood, A Muzzi… - Proceedings of the …, 2014 - National Acad Sciences
One of the main hurdles for the development of an effective and broadly protective vaccine
against nonencapsulated isolates of Haemophilus influenzae (NTHi) lies in the genetic …

[HTML][HTML] Genetic Diversity of Antimicrobial Resistance and Key Virulence Features in Two Extensively Drug-Resistant Acinetobacter baumannii Isolates

M Marazzato, D Scribano, M Sarshar, F Brunetti… - International Journal of …, 2022 - mdpi.com
In recent decades, Acinetobacter baumannii emerged as a major infective menace in
healthcare settings due to scarce therapeutic options to treat infections. Therefore …

[HTML][HTML] Molecular Signatures of Non-typeable Haemophilus influenzae Lung Adaptation in Pediatric Chronic Lung Disease

A Aziz, DS Sarovich, E Nosworthy… - Frontiers in …, 2019 - frontiersin.org
Non-typeable Haemophilus influenzae (NTHi), an opportunistic pathogen of the upper
airways of healthy children, can infect the lower airways, driving chronic lung disease …