Pulmonary pyruvate metabolism as an index of inflammation and injury in a rat model of acute respiratory distress syndrome
Increased pulmonary lactate production is correlated with severity of lung injury and
outcome in acute respiratory distress syndrome (ARDS) patients. This study was conducted …
outcome in acute respiratory distress syndrome (ARDS) patients. This study was conducted …
Lung metabolism and inflammation during mechanical ventilation; an imaging approach
Acute respiratory distress syndrome (ARDS) is a major cause of mortality in critically ill
patients. Patients are currently managed by protective ventilation and alveolar recruitment …
patients. Patients are currently managed by protective ventilation and alveolar recruitment …
Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injury
NJ Serkova, Z Van Rheen, M Tobias… - … -Lung Cellular And …, 2008 - journals.physiology.org
Magnetic resonance imaging (MRI) and metabolic nuclear magnetic resonance (NMR)
spectroscopy are clinically available but have had little application in the quantification of …
spectroscopy are clinically available but have had little application in the quantification of …
The effect of exogenous substrate concentrations on true and apparent metabolism of hyperpolarized pyruvate in the isolated perfused lung
S Kadlecek, H Shaghaghi, S Siddiqui… - NMR in …, 2014 - Wiley Online Library
Although relatively metabolically inactive, the lung has an important role in maintaining
systemic glycolytic intermediate and cytosolic redox balance. Failure to perform this function …
systemic glycolytic intermediate and cytosolic redox balance. Failure to perform this function …
Metabolomic analysis of pulmonary tissue in an experimental model of ventilator induced lung injury
N NIN, JL IZQUIERDO, Y Rojas… - A25. TRANSLATING …, 2011 - atsjournals.org
BACKGROUND: Currently there is no molecular biomarker indicative of pulmonary epithelial
cell injury in acute lung injury (ALI). Assessment of global metabolic profiling using …
cell injury in acute lung injury (ALI). Assessment of global metabolic profiling using …
Altered metabolic function of the pulmonary microcirculation: Early detection of lung injury and possible functional significance
HP Wiedemann, CN Gillis - Critical Care Clinics, 1986 - criticalcare.theclinics.com
The normal lung is the site of intense metabolic activity, largely associated with the
microvascular endothelial cells. Depressed pulmonary metabolic function is demonstrated in …
microvascular endothelial cells. Depressed pulmonary metabolic function is demonstrated in …
Ventilation Defects Observed with Hyperpolarized 3He Magnetic Resonance Imaging in a Mouse Model of Acute Lung Injury
AC Thomas, JC Nouls, B Driehuys… - American Journal of …, 2011 - atsjournals.org
Regions of diminished ventilation are often evident during functional pulmonary imaging
studies, including hyperpolarized gas magnetic resonance imaging (MRI), positron emission …
studies, including hyperpolarized gas magnetic resonance imaging (MRI), positron emission …
Assessment of the influence of lung inflation state on the quantitative parameters derived from hyperpolarized gas lung ventilation MRI in healthy volunteers
In this study, the effect of lung volume on quantitative measures of lung ventilation was
investigated using MRI with hyperpolarized 3He and 129Xe. Six volunteers were imaged …
investigated using MRI with hyperpolarized 3He and 129Xe. Six volunteers were imaged …
In vivo molecular imaging stratifies rats with different susceptibilities to hyperoxic acute lung injury
99mTc-hexamethylpropyleneamine oxime (HMPAO) and 99mTc-duramycin in vivo imaging
detects pulmonary oxidative stress and cell death, respectively, in rats exposed to> 95% O2 …
detects pulmonary oxidative stress and cell death, respectively, in rats exposed to> 95% O2 …
Ethyl pyruvate reduces acute lung damage following trauma and hemorrhagic shock via inhibition of NF-κB and HMGB1
B Relja, N Wagner, N Franz, S Dieteren, K Mörs… - Immunobiology, 2018 - Elsevier
Objective After blunt thoracic trauma (TxT) and hemorrhagic shock with resuscitation (H/R)
intense local inflammatory response and cell loss frequently impair the pulmonary function …
intense local inflammatory response and cell loss frequently impair the pulmonary function …