Microglial annexin A3 downregulation alleviates bone cancer-induced pain through inhibiting the Hif-1α/vascular endothelial growth factor signaling pathway
Z Zhang, M Deng, J Huang, J Wu, Z Li, M Xing, J Wang… - Pain, 2020 - journals.lww.com
Bone cancer-induced pain (BCP) is a challenging clinical problem because traditional
therapies are often only partially effective. Annexin A3 (ANXA3) is highly expressed in …
therapies are often only partially effective. Annexin A3 (ANXA3) is highly expressed in …
Knockdown of annexin-A1 inhibits growth, migration and invasion of glioma cells by suppressing the PI3K/Akt signaling pathway
L Wei, L Li, L Liu, R Yu, X Li, Z Luo - ASN neuro, 2021 - journals.sagepub.com
ANXA1, which can bind phospholipid in a calcium dependent manner, is reported to play a
pivotal role in tumor progression. However, the role and mechanism of ANXA1 involved in …
pivotal role in tumor progression. However, the role and mechanism of ANXA1 involved in …
The involvement of spinal annexin A10/NF-κB/MMP-9 pathway in the development of neuropathic pain in rats
LH Sun, Q Xu, WX Zhang, CC Jiao, H Wu, XZ Chen - BMC neuroscience, 2019 - Springer
Background Neuropathic pain (NP) is a prevalent disease, which badly impairs the life
quality of patients. The underlying mechanism of NP is still not fully understood. It has been …
quality of patients. The underlying mechanism of NP is still not fully understood. It has been …
Annexin 1 inhibits remifentanil-induced hyperalgesia and NMDA receptor phosphorylation via regulating spinal CXCL12/CXCR4 in rats
T Li, H Wang, J Wang, Y Chen, C Yang, M Zhao… - Neuroscience …, 2019 - Elsevier
Chemokines related neuroinflammation and N-methyl-d-aspartate receptor (NMDAR)
mediated nociceptive transmission are pivotal determinants in the pathogenesis of opioid …
mediated nociceptive transmission are pivotal determinants in the pathogenesis of opioid …
The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons
Y Zhang, S Ma, X Ke, Y Yi, H Yu, D Yu, Q Li, Y Shang… - Cell & Bioscience, 2021 - Springer
Abstract Background Annexin A1 (ANXA1) exerts anti-nociceptive effect through ANXA1
receptor formyl peptide receptor 2 (FPR2/ALX (receptor for lipoxin A4), FPR2) at the dorsal …
receptor formyl peptide receptor 2 (FPR2/ALX (receptor for lipoxin A4), FPR2) at the dorsal …
Annexin A3 accelerates osteoclast differentiation by promoting the level of RANK and TRAF6
S Lin, M Li, Y Zhou, L Chen, Y Wang, Z Zhuang… - Bone, 2023 - Elsevier
Abstract Annexin A3 (ANXA3), a member of Annexin family, is reported to mediate
membrane transport and cancer development. However, the effect of ANXA3 on osteoclast …
membrane transport and cancer development. However, the effect of ANXA3 on osteoclast …
Resveratrol attenuates bone cancer pain through regulating the expression levels of ASIC3 and activating cell autophagy
H Zhu, J Ding, J Wu, T Liu, J Liang… - Acta Biochimica et …, 2017 - academic.oup.com
Bone cancer pain (BCP) is one of the most common pains in patients with malignant
cancers. The mechanism underlying BCP is largely unknown. Our previous studies and the …
cancers. The mechanism underlying BCP is largely unknown. Our previous studies and the …
ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis
S Ma, CC Lu, LY Yang, JJ Wang, BS Wang… - Journal of Experimental …, 2018 - Springer
Abstract Background ANXA2 (Annexin A2) is a pleiotropic calcium-dependent phospholipid
binding protein that is abnormally expressed in various cancers. We previously found that …
binding protein that is abnormally expressed in various cancers. We previously found that …
[HTML][HTML] Annexin A5 suppresses cyclooxygenase-2 expression by downregulating the protein kinase C-ζ–nuclear factor-κB signaling pathway in prostate cancer cells
HS Baek, N Park, YJ Kwon, DJ Ye, S Shin, YJ Chun - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Annexin A5 (ANXA5) is a member of the annexin protein family. Previous studies
have shown that ANXA5 is involved in anti-inflammation and cell death. However, the …
have shown that ANXA5 is involved in anti-inflammation and cell death. However, the …
Annexin-1 mimetic peptide Ac2-26 suppresses inflammatory mediators in LPS-induced astrocytes and ameliorates pain hypersensitivity in a rat model of inflammatory …
Z Luo, H Wang, S Fang, L Li, X Li, J Shi, M Zhu… - Cellular and molecular …, 2020 - Springer
Abstract Ac2-26, a mimetic peptide of Annexin-A1, plays a vital role in the anti-inflammatory
response mediated by astrocytes. In this study, we aimed to explore the underlying …
response mediated by astrocytes. In this study, we aimed to explore the underlying …