The E3 ubiquitin ligase SIAH1 targets MyD88 for proteasomal degradation during dengue virus infection

AR Murphy Schafer, JL Smith, KM Pryke… - Frontiers in …, 2020 - frontiersin.org
The dengue virus presents a serious threat to human health globally and can cause severe,
even life-threatening, illness. Dengue virus (DENV) is endemic on all continents except …

Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling

J Morrison, M Laurent-Rolle, AM Maestre… - PLoS …, 2013 - journals.plos.org
An estimated 50 million dengue virus (DENV) infections occur annually and more than forty
percent of the human population is currently at risk of developing dengue fever (DF) or …

Endoplasmic reticulum protein SCAP inhibits dengue virus NS2B3 protease by suppressing its K27-linked polyubiquitylation

H Liu, L Zhang, J Sun, W Chen, S Li, Q Wang… - Journal of …, 2017 - Am Soc Microbiol
Dengue viruses (DENVs) are an emerging threat to global public health. The NS2B3
protease complex of DENV has recently been shown to cleave the antiviral protein STING …

Host factor DUSP5 potently inhibits dengue virus infection by modulating cytoskeleton rearrangement

M Liang, Y Li, K Zhang, Y Zhu, J Liang, M Liu, S Zhang… - Antiviral Research, 2023 - Elsevier
Cytoskeleton has been reported to play an essential role in facilitating the viral life cycle.
However, whether the host can exert its antiviral effects by modulating the cytoskeleton is not …

Dengue virus targets the adaptor protein MITA to subvert host innate immunity

CY Yu, TH Chang, JJ Liang, RL Chiang, YL Lee… - PLoS …, 2012 - journals.plos.org
Dengue is one of the most important arboviral diseases caused by infection of four serotypes
of dengue virus (DEN). We found that activation of interferon regulatory factor 3 (IRF3) …

Dengue virus degrades USP33–ATF3 axis via extracellular vesicles to activate human microglial cells

R Mishra, A Lahon, AC Banerjea - The Journal of Immunology, 2020 - journals.aai.org
Dengue virus (DENV) infection disrupts host innate immune signaling at various
checkpoints. Cellular levels and stability of intermediate signaling molecules are a crucial …

STAT2 signaling and dengue virus infection

J Morrison, A García-Sastre - Jak-stat, 2014 - Taylor & Francis
Dengue virus (DENV) is an important human pathogen whose byzantine relationship with
the immune response is poorly understood. DENV causes dengue fever and dengue …

Innate immunity to dengue virus infection and subversion of antiviral responses

AM Green, PR Beatty, A Hadjilaou, E Harris - Journal of molecular biology, 2014 - Elsevier
Dengue is a major public health issue in tropical and subtropical regions worldwide. The
four serotypes of dengue virus (DENV1–DENV4) are spread primarily by Aedes aegypti and …

Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation

MM Gonzalez Lopez Ledesma… - Proceedings of the …, 2023 - National Acad Sciences
Dengue virus (DENV) is the most important human virus transmitted by mosquitos. Dengue
pathogenesis is characterized by a large induction of proinflammatory cytokines. This …

Knockdown of NEAT1 restricts dengue virus replication by augmenting interferon alpha-inducible protein 27 via the RIG-I pathway

J Saini, U Thapa, B Bandyopadhyay… - Journal of General …, 2023 - microbiologyresearch.org
The lncRNA NEAT1 plays a vital role in mitochondrial function and antiviral response. We
have previously identified NEAT1 as dysregulated lncRNAs and found an inverse …