Biotin is an essential cofactor for carboxylases that regulates the energy metabolism.
Recently, high‐dose pharmaceutical‐grade biotin (MD1003) was shown to improve clinical …

Progressive multiple sclerosis (MS) is a severely disabling neurological condition, and an
effective treatment is urgently needed. Recently, high-dose biotin has emerged as a …

Mitochondrial and metabolic dysfunction are often implicated in neurological disease, but
effective mechanism-based therapies remain elusive. We performed a genome-scale …

Mechanisms implicated in disease progression in multiple sclerosis include continued
oligodendrocyte (OL)/myelin injury and failure of myelin repair. Underlying causes include …

Accumulating evidences suggest a strong correlation between metabolic changes and
neurodegeneration in CNS demyelinating diseases such as multiple sclerosis (MS). Biotin …

Mitochondrial dysfunction and oxidative stress are involved in neurodegenerative diseases
associated with an enhancement of lipid peroxidation products such as 7β …

Abstract X-linked adrenoleukodystrophy (X-ALD) is the most frequent inherited monogenic
demyelinating disease (minimal incidence 1: 17,000). It is often lethal and currently lacks a …

Background Biotin may activate the acetyl-CoA-, 3-methylcrotonyl-CoA-, propionyl-CoA-,
and pyruvate carboxylases to increase myelin repair and/or synthesis, and may enhance the …

Biotin is the prosthetic group of carboxylases that have important roles in the metabolism of
glucose, fatty acids and amino acids. Biotinidase has a key role in the reutilization of the …

Autophagy delays the onset of endoplasmic reticulum (ER) stress by recycling cellular
debris. However, the cues that elicit autophagy under the emergence of ER stress and their …