Accumulating discoveries highlight the importance of interaction between marrow stromal
cells and cancer cells for bone metastasis. Bone is the most common metastatic site of …

The morbidity and mortality of breast cancer is mostly due to a distant metastasis, especially
to the bone. Many factors may be responsible for bone metastasis in breast cancer, but …

The high incidences of bone metastasis in patients with breast cancer, prostate cancer and
lung cancer still remains a puzzling issue. The “seeds and soil” hypothesis suggested that …

Cancer is a complex disease, with various pre-existing health ailments enhancing its
pathology. In cancer, the extracellular environment contains various intrinsic physiological …

Purpose Bone marrow adipocytes (BMAs) are the most plentiful cells in the bone marrow
and function as an endocrine organ by producing fatty acids, cytokines, and adipokines …

Bone marrow adipocytes (BMAs) represent 10% of the total fat mass of the human body and
serve as an energy reservoir for the skeletal niche. They function as an endocrine organ by …

Bone metastasis occurs frequently in cancer patients. Conventional therapies have limited
therapeutic outcomes, and thus, exploring the mechanisms of cancer progression in bone …

The bone marrow is a favored site for a number of cancers, including the hematological
malignancy multiple myeloma, and metastasis of breast and prostate cancer. This …

Bone is a common site of metastasis for lung cancer. The “seed and soil” hypothesis
suggests that the bone marrow microenvironment (“soil”) may provide a conducive survival …

Bone is the most common metastatic site in breast cancer. Upon arrival to the bone,
disseminated tumor cells can undergo a period of dormancy but often eventually grow and …