Update on SLC6A14 in lung and gastrointestinal physiology and physiopathology: focus on cystic fibrosis

M Ruffin, J Mercier, C Calmel, J Mésinèle… - Cellular and Molecular …, 2020 - Springer
The solute carrier family 6 member 14 (SLC6A14) protein imports and concentrates all
neutral amino acids as well as the two cationic acids lysine and arginine into the cytoplasm …

SLC26A9 as a potential modifier and therapeutic target in cystic fibrosis lung disease

G Gorrieri, F Zara, P Scudieri - Biomolecules, 2022 - mdpi.com
SLC26A9 belongs to the solute carrier family 26 (SLC26), which comprises membrane
proteins involved in ion transport mechanisms. On the basis of different preliminary findings …

SLC26A9 in airways and intestine: secretion or absorption?

K Kunzelmann, R Centeio, J Ousingsawat, K Talbi… - Channels, 2023 - Taylor & Francis
ABSTRACT SLC26A9 is one out of 11 proteins that belong to the SLC26A family of anion
transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the …

Synergy in cystic fibrosis therapies: targeting SLC26A9

MC Pinto, MC Quaresma, IAL Silva, V Railean… - International journal of …, 2021 - mdpi.com
SLC26A9, a constitutively active Cl− transporter, has gained interest over the past years as a
relevant disease modifier in several respiratory disorders including Cystic Fibrosis (CF) …

SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells

M Di Paola, AJ Park, S Ahmadi, EJ Roach, YS Wu… - MBio, 2017 - Am Soc Microbiol
Cystic fibrosis (CF) is caused by mutations in the CFTR gene and is associated with
progressive and ultimately fatal infectious lung disease. There can be considerable …

Role of the SLC26A9 chloride channel as disease modifier and potential therapeutic target in cystic fibrosis

A Balázs, MA Mall - Frontiers in pharmacology, 2018 - frontiersin.org
The solute carrier family 26, member 9 (SLC26A9) is an epithelial chloride channel that is
expressed in several organs affected in patients with cystic fibrosis (CF) including the lungs …

Modulatory effect of the SLC9A3 gene on susceptibility to infections and pulmonary function in children with cystic fibrosis

R Dorfman, C Taylor, F Lin, L Sun… - Pediatric …, 2011 - Wiley Online Library
In cystic fibrosis (CF), CFTR dysfunction leads to salt and water imbalance across airway
epithelia, depleted surface liquid layer, and impaired mucociliary clearance. This provides …

Functional interaction of the cystic fibrosis transmembrane conductance regulator with members of the SLC26 family of anion transporters (SLC26A8 and SLC26A9) …

E El Khouri, A Touré - The international journal of biochemistry & cell …, 2014 - Elsevier
Abstract The solute carrier 26 (SLC26) proteins are transmembrane proteins located at the
plasma membrane of the cells and transporting a variety of monovalent and divalent anions …

Physiological and pathophysiological relevance of the anion transporter Slc26a9 in multiple organs

X Liu, T Li, B Tuo - Frontiers in physiology, 2018 - frontiersin.org
Transepithelial Cl-and HCO3-transport is crucial for the function of all epithelia, and HCO3-is
a biological buffer that maintains acid-base homeostasis. In most epithelia, a series of Cl …

Expression of SLC26A9 in airways and its potential role in asthma

J Ousingsawat, R Centeio, R Schreiber… - International journal of …, 2022 - mdpi.com
SLC26A9 is an epithelial anion transporter with a poorly defined function in airways. It is
assumed to contribute to airway chloride secretion and airway surface hydration. However …