Single-cell RNA-seq analysis of human CSF microglia and myeloid cells in neuroinflammation
E Esaulova, C Cantoni, I Shchukina… - Neurology …, 2020 - AAN Enterprises
Objective To identify and characterize myeloid cell populations within the CSF of patients
with MS and anti-myelin oligodendrocyte glycoprotein (MOG) disorder by high-resolution …
with MS and anti-myelin oligodendrocyte glycoprotein (MOG) disorder by high-resolution …
RNA sequencing of microglia and monocyte-derived macrophages from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with …
ND Lewis, JD Hill, KW Juchem… - Journal of …, 2014 - Elsevier
The role of microglia and monocyte-derived macrophages in experimental autoimmune
encephalomyelitis pathogenesis has been controversial. To gain insight into their respective …
encephalomyelitis pathogenesis has been controversial. To gain insight into their respective …
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation
MJC Jordão, R Sankowski, SM Brendecke, Sagar… - Science, 2019 - science.org
INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …
Pathologic and protective roles for microglial subsets and bone marrow-and blood-derived myeloid cells in central nervous system inflammation
A Wlodarczyk, O Cédile, KN Jensen, A Jasson… - Frontiers in …, 2015 - frontiersin.org
Inflammation is a series of processes designed for eventual clearance of pathogens and
repair of damaged tissue. In the context of autoimmune recognition, inflammatory processes …
repair of damaged tissue. In the context of autoimmune recognition, inflammatory processes …
Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models
Neuroinflammation and neurodegeneration may represent two poles of brain pathology.
Brain myeloid cells, particularly microglia, play key roles in these conditions. We employed …
Brain myeloid cells, particularly microglia, play key roles in these conditions. We employed …
CSF microRNAs discriminate MS activity and share similarity to other neuroinflammatory disorders
O Perdaens, HA Dang, L D'Auria… - Neurology …, 2020 - AAN Enterprises
Objective To perform a comprehensive multicompartment analysis of microRNA (miRNA)
expression in multiple sclerosis (MS) linked to disease activity and compared with other …
expression in multiple sclerosis (MS) linked to disease activity and compared with other …
Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
D Schafflick, CA Xu, M Hartlehnert, M Cole… - Nature …, 2020 - nature.com
Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …
Transcriptomic and clonal characterization of T cells in the human central nervous system
JL Pappalardo, L Zhang, MK Pecsok, K Perlman… - Science …, 2020 - science.org
T cells provide critical immune surveillance to the central nervous system (CNS), and the
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further …
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further …
Microglia diversity in healthy and diseased brain: insights from single-cell omics
N Ochocka, B Kaminska - International journal of molecular sciences, 2021 - mdpi.com
Microglia are the resident immune cells of the central nervous system (CNS) that have
distinct ontogeny from other tissue macrophages and play a pivotal role in health and …
distinct ontogeny from other tissue macrophages and play a pivotal role in health and …
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
A Miedema, E Gerrits, N Brouwer, Q Jiang… - Acta neuropathologica …, 2022 - Springer
Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by
inflammation and focal areas of demyelination, ultimately resulting in axonal degradation …
inflammation and focal areas of demyelination, ultimately resulting in axonal degradation …