Toxicity from drugs has become an important cause of acute liver failure. Acetaminophen, a
commonly used analgesic, can cause severe acute liver injury that can worsen into acute …

Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure in the USA
and many other countries. Although the metabolism and pathogenesis of APAP has been …

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug. APAP overdose
can induce acute liver injury in humans, which is responsible for approximately 50% of total …

Background & Aims Acetaminophen (APAP)-induced liver injury is the most frequent cause
of acute liver failure in the US and many other countries. Metabolism of APAP results in …

Autophagy can selectively remove damaged organelles, including mitochondria, and, in
turn, protect against mitochondria‐damage–induced cell death. Acetaminophen (APAP) …

Background Previous reports indicate that mitochondrial dysfunction is essential for the
development of liver injury due to acetaminophen. On the other hand, autophagy, which is a …

Autophagy, a lysosomal catabolic pathway for long‐lived proteins and damaged organelles,
is crucial for cell homeostasis, and survival under stressful conditions. During starvation …

Autophagy is a lysosomal degradation pathway for bulk cytosolic proteins and damaged
organelles, and is well known to act as a cell survival mechanism. Acetaminophen (APAP) …

Acetaminophen (APA)-induced hepatotoxicity is coupled with the activation of autophagy.
We sought to determine whether selective autophagy of the endoplasmic reticulum (ER) …

Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure in the US
and many western countries. It is well known that APAP induces mitochondrial damage to …