Crohn's disease (CD) is a chronic inflammatory disease of unknown etiology that covers the
entire digestive tract and occurs with periods of remission and clinical exacerbation. CD is …

Background—Expression of pro-inflammatory cytokines is increased in the intestinal lamina
propria of patients with inflammatory bowel disease (IBD). Nuclear factor κB (NFκB) controls …

Objectives and Design: The location and degree of activation of nuclear factor kappa
(NFκB), a primary transcription factor that plays a regulating role in immune and …

The events initiating the inflammatory processes in the chronic inflammatory bowel disease,
Crohn's disease, are poorly understood. NFKB is a central, regulating element in many …

Nuclear factor-κB (NF-κB) is the main target of anti-inflammatory therapies in human chronic
inflammatory bowel diseases (IBD), Crohn disease, and ulcerative colitis. This study …

The treatment with infliximab is employed successfully in Crohn's disease (CD) but
predictors of efficacy are lacking. Activation of the transcription factor NF-kB has been …

Despite considerable progress elucidating the cellular and molecular events associated with
chronic inflammatory bowel diseases (IBD), the etiology of Crohn's disease (CD) and …

Apart from genetic and environmental factors, the mucosal immune system of the gut plays a
central role in the pathogenesis of inflammatory bowel disease (IBD). In the healthy gut, the …

Nuclear factor-kappa-B (NF-κB) is considered a central mediator of the immune response.
Well over 100 genes are activated by this transcription factor and most of them are directly or …

The nuclear factor κB (NF-κB) took the field of inflammatory research by storm in the late
1980s. In search of a B-cell-specific transcription factor involved in the transcriptional …