Pharmacogenetic profile and the development of the dyskinesia induced by levodopa-therapy in Parkinson's disease patients: a population-based cohort study

EUD Dos Santos, IIFG da Silva, AGC Asano… - Molecular Biology …, 2020 - Springer
Levodopa-induced dyskinesia (LID) is an adverse effect that negatively impacts the quality
of life of patients with Parkinson's disease (PD). Studies report that genetic variations in the …

Polymorphisms of dopamine receptor genes and risk of l-dopa–induced dyskinesia in parkinson's disease

C Comi, M Ferrari, F Marino, L Magistrelli… - International journal of …, 2017 - mdpi.com
L-dopa–induced dyskinesia (LID) is a frequent motor complication of Parkinson's disease
(PD), associated with a negative prognosis. Previous studies showed an association …

DAT gene polymorphisms (rs28363170, rs393795) and levodopa-induced dyskinesias in Parkinson's disease

C Purcaro, N Vanacore, F Moret, ME Di Battista… - Neuroscience …, 2019 - Elsevier
L-dopa–induced dyskinesias (LID) is a common motor side effect of levodopa therapy of
Parkinson's disease (PD). The identified predictors may only partially account for the risk of …

Association of catechol-O-methyltransferase gene rs4680 polymorphism and levodopa induced dyskinesia in Parkinson's disease: a meta-analysis and systematic …

A Dwivedi, N Dwivedi, A Kumar… - Journal of Geriatric …, 2023 - journals.sagepub.com
Introduction Long-term levodopa therapy for Parkinson's disease (PD) can cause levodopa
induced dyskinesia (LID). Genetic predisposition has a significant role to play in inter …

Influence of DRD1 and DRD3 Polymorphisms in the Occurrence of Motor Effects in Patients with Sporadic Parkinson's Disease

EUD Dos Santos, EBC Duarte, LMR Miranda… - NeuroMolecular …, 2019 - Springer
Parkinson's disease (PD) is a multisystem disorder that affects 2–3% of the population≥ 65
years of age. The main pharmacologic agent use in the treatment of clinical symptoms of PD …

DRD2 haplotype is associated with dyskinesia induced by levodopa therapy in Parkinson's disease patients

M Rieck, AF Schumacher-Schuh, V Altmann… - …, 2012 - Future Medicine
Aim: Dyskinesia and motor fluctuation are frequent and serious complications of chronic
levodopa therapy in patients with Parkinson's disease. Since genetic factors could play a …

Sequence Variants in SLC6A3, DRD2, and BDNF Genes and Time to Levodopa-Induced Dyskinesias in Parkinson's Disease

N Kaplan, A Vituri, AD Korczyn, OS Cohen… - Journal of Molecular …, 2014 - Springer
Levodopa-induced dyskinesias (LID) present a common but elusive complication of
levodopa therapy in Parkinson's disease (PD). In order to identify genetic factors associated …

Genetic variants in levodopa-induced dyskinesia (LID): a systematic review and meta-analysis

M Falla, A Di Fonzo, AA Hicks, PP Pramstaller… - Parkinsonism & Related …, 2021 - Elsevier
Introduction Levodopa-induced dyskinesia frequently complicates long-term Parkinson's
disease. More in-depth knowledge regarding the role of genetic factors in dyskinesia …

Associations between variants in levodopa metabolic pathway genes and levodopa-induced dyskinesia in Parkinson's disease

JH Yan, YL Ge, PZ Wang, W Li, H Jin, JR Zhang… - Neuroscience …, 2023 - Elsevier
Introduction Levodopa-induced dyskinesia (LID) is a common motor complication in
Parkinson's disease (PD). Several genes in the levodopa metabolic pathway, such as …

Association of COMT rs4680 and MAO-B rs1799836 polymorphisms with levodopa-induced dyskinesia in Parkinson's disease—a meta-analysis

Y Yin, Y Liu, M Xu, XM Zhang, C Li - Neurological Sciences, 2021 - Springer
Background and purpose Polymorphisms of the catechol-O-methyl transferase (COMT) or
monoamine oxidase B (MAO-B) genes may affect the occurrence of dyskinesia in …