To identify epigenetically silenced miRNAs and to investigate their influences on predictive
target oncogenes in extranodal natural killer/T-cell lymphoma (NKTCL). Decitabine …

Background miR-1250 is localised to the second intron of AATK at chromosome 17q25. As a
CpG island is present at the putative promoter region of its host gene, AATK, we postulated …

Natural killer/T-cell lymphoma (NKTCL) is characterized by its highly aggressive nature and
rapid progression. MicroRNAs (miRNAs) play key roles in the development of NKTCL. We …

The discovery of microRNA (miRNA) has provided new and powerful tools for studying the
mechanism, diagnosis and treatment of human cancers. The down-regulation of tumor …

T cell acute lymphoblastic leukaemia (T‐ALL) is a highly aggressive haematological cancer
of the bone marrow. The abnormal expression of microRNAs (miRNAs) is reportedly …

Objective To study the expression of microRNAs (miRNAs) in extranodal NK/T cell
lymphoma, nasal type (EN-NK/T-NT). Methods TaqMan low density arrays were used to …

Background MIR129-2 has been shown to be a tumor suppressor microRNA
hypermethylated in epithelial cancers. Patients and methods Epigenetic inactivation of …

miRNAs are a group of small noncoding RNAs measuring 19–25 nucleotides. Sequence-
specific binding of miRNAs to the 3´ untranslated regions of target genes leads to …

We performed a comprehensive genome-wide miRNA expression profiling of extranodal
nasal-type natural killer/T-cell lymphoma (NKTL) using formalin-fixed paraffin-embedded …

Whereas transcriptional silencing of genes due to epigenetic mechanisms is one of the most
important alterations in acute lymphoblastic leukemia (ALL), some recent studies indicate …