Mass spectrometry-based technology and workflows for studying the chemistry of fungal endophyte derived bioactive compounds

P Gupta, A Verma, N Rai, AK Singh… - ACS Chemical …, 2021 - ACS Publications
Bioactive compounds have gained substantial attention in research and have conferred
great advancements in the industrial and pharmacological fields. Highly diverse fungi and …

[HTML][HTML] Natural products dereplication by diffusion ordered NMR spectroscopy (DOSY)

G Kleks, DC Holland, J Porter, AR Carroll - Chemical Science, 2021 - pubs.rsc.org
Diffusion-ordered NMR spectroscopy (DOSY) can be used to analyze mixtures of
compounds since resonances deriving from different compounds are distinguished by their …

Sarcaglarols A—D, Lindenane−Monoterpene Heterodimers from Sarcandra glabra Based on Molecular Networks

Y Wang, Z Cui, J Chi, P Tang, M Zhang… - Chinese Journal of …, 2021 - Wiley Online Library
Main observation and conclusion Sarcaglarols A—D (1—4), two pairs of lindenane−
monoterpene heterodimers fused by a 1, 2‐dioxane moiety, were discovered and isolated …

[HTML][HTML] Metabolomics as a tool to study underused soy parts: In search of bioactive compounds

FS Bragagnolo, CS Funari, E Ibáñez, A Cifuentes - Foods, 2021 - mdpi.com
The valorization of agri-food by-products is essential from both economic and sustainability
perspectives. The large quantity of such materials causes problems for the environment; …

Predicting biochemical and physiological effects of natural products from molecular structures using machine learning

J Jeon, S Kang, HU Kim - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2016 to 2021 Discovery of novel natural products has been greatly facilitated by
advances in genome sequencing, genome mining and analytical techniques. As a result, the …

[HTML][HTML] Insulin-Mimic Components in Acer truncatum Leaves: Bio-Guided Isolation, Annual Variance Profiling and Regulating Pathway Investigated by Omics

XY Zhang, YH Liu, DZ Liu, JY Xu, Q Zhang - Pharmaceuticals, 2021 - mdpi.com
Insulin mimic can promote transporting glucose to muscle tissue and accelerate glucose
consumption. It is commonly occurring in many functional foods or traditional medicines. Anti …

Vibsane-type diterpenoids from Viburnum odoratissimum and their cytotoxic activities

SF Li, XQ Yu, YL Li, M Bai, B Lin, GD Yao, SJ Song - Bioorganic Chemistry, 2021 - Elsevier
Abstract Seven new diterpenoids (1–7), including five 7-membered ring vibsane-type
diterpenoids, vibsanolide AE (1–5) and a pair of epimers of 14, 15, 16, 17-tetranorvibsane …

Combining NMR-based metabolic profiling and genome mining for the accelerated discovery of Archangiumide, an Allenic Macrolide from the Myxobacterium …

JQ Hu, JJ Wang, YL Li, L Zhuo, A Zhang, HY Sui… - Organic …, 2021 - ACS Publications
An unprecedented 19-membered allenic macrolide archangiumide (1) was discovered from
the myxobacterium Archangium violaceum SDU8 by integrating NMR-based metabolic …

[HTML][HTML] Biocatalytic synthesis of peptidic natural products and related analogues

D Liu, GM Rubin, D Dhakal, M Chen, Y Ding - Iscience, 2021 - cell.com
Peptidic natural products (PNPs) represent a rich source of lead compounds for the
discovery and development of therapeutic agents for the treatment of a variety of diseases …

[HTML][HTML] Metabolomics-guided elucidation of plant abiotic stress responses in the 4IR era: An Overview

MM Tinte, KH Chele, JJJ van Der Hooft, F Tugizimana - Metabolites, 2021 - mdpi.com
Plants are constantly challenged by changing environmental conditions that include abiotic
stresses. These are limiting their development and productivity and are subsequently …