Genome-wide association studies of Systemic Lupus Erythematosus (SLE) nominate 3073
genetic variants at 91 risk loci. To systematically screen these variants for allelic …

d-amino acids are increasingly recognized as important signaling molecules in the
mammalian central nervous system. However, the d-stereoisomer of the amino acid with the …

X-linked dystonia-parkinsonism is a neurodegenerative disorder caused by a founder
retrotransposon insertion, in which a polymorphic hexanucleotide repeat accounts for~ 50 …

Nuclear compartments are thought to play a role in three-dimensional genome organization
and gene expression. In mammalian brain, the architecture and dynamics of nuclear …

Exosomes are involved in the pathophysiology of neuropsychiatric diseases, but the role of
exosomes in schizophrenia (SCZ) is unclear. Here, we demonstrate that transplantation of …

Schizophrenia is a severe neuropsychiatric disorder with core features including
hallucinations, delusions, and cognition deficits. Accumulating evidence has implicated …

The recognition that schizophrenia is a disorder of neurodevelopment is widely accepted.
The original hypothesis was coined more than 30 years ago and the wealth of supportive …

The classical M1/M2 polarity of macrophages may not be applicable to inflammatory lung
diseases including chronic obstructive pulmonary disease (COPD) due to the complex …

Patients with schizophrenia experience cognitive dysfunction and negative symptoms that
do not respond to current drug treatments. Historical evidence is consistent with the …

Neuropsychiatric phenotypes have long been known to be influenced by heritable risk
factors, directly confirmed by the past decade of genetic studies that have revealed specific …