Inflammation and JNK's role in niacin-GPR109A diminished flushed effect in microglial and neuronal cells with relevance to schizophrenia
SH Ansarey - Frontiers in Psychiatry, 2021 - frontiersin.org
Schizophrenia is a neuropsychiatric illness with no single definitive aetiology, making its
treatment difficult. Antipsychotics are not fully effective because they treat psychosis rather …
treatment difficult. Antipsychotics are not fully effective because they treat psychosis rather …
Cortical cellular diversity and development in schizophrenia
While a definitive understanding of schizophrenia etiology is far from current reality, an
increasing body of evidence implicates perturbations in early development that alter the …
increasing body of evidence implicates perturbations in early development that alter the …
Characterizing the dynamic and functional DNA methylation landscape in the developing human cortex
KA Perzel Mandell, AJ Price, R Wilton… - Epigenetics, 2021 - Taylor & Francis
ABSTRACT DNA methylation (DNAm) is a key epigenetic regulator of gene expression
across development. The developing prenatal brain is a highly dynamic tissue, but our …
across development. The developing prenatal brain is a highly dynamic tissue, but our …
Allele-specific DNA methylation maps in monozygotic twins discordant for psychiatric disorders reveal that disease-associated switching at the EIPR1 regulatory loci …
Q Li, Z Wang, L Zong, L Ye, J Ye, H Ou, T Jiang… - Molecular …, 2021 - nature.com
The non-Mendelian features of phenotypic variations within monozygotic twins are likely
complicated by environmental modifiers of genetic effects that have yet to be elucidated …
complicated by environmental modifiers of genetic effects that have yet to be elucidated …
Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene
Y Zhang, S Li, X Li, Y Yang, W Li, X Xiao, M Li… - Journal of Medical …, 2021 - jmg.bmj.com
The association between NOTCH4 and schizophrenia has been repeatedly reported.
However, the results from different genetic studies are inconsistent, and the role of NOTCH4 …
However, the results from different genetic studies are inconsistent, and the role of NOTCH4 …
nMAGMA: a network-enhanced method for inferring risk genes from GWAS summary statistics and its application to schizophrenia
A Yang, J Chen, XM Zhao - Briefings in bioinformatics, 2021 - academic.oup.com
Motivation: Annotating genetic variants from summary statistics of genome-wide association
studies (GWAS) is crucial for predicting risk genes of various disorders. The multimarker …
studies (GWAS) is crucial for predicting risk genes of various disorders. The multimarker …
Integrative Analyses Followed by Functional Characterization Reveal TMEM180 as a Schizophrenia Risk Gene
JY Wang, XY Li, HJ Li, JW Liu, YG Yao, M Li… - Schizophrenia …, 2021 - academic.oup.com
Recent large-scale integrative analyses (including Transcriptome-Wide Association Study
[TWAS] and Summary-data-based Mendelian Randomization [SMR]) have identified …
[TWAS] and Summary-data-based Mendelian Randomization [SMR]) have identified …
Functional variants fine‐mapping and gene function characterization provide insights into the role of ZNF323 in schizophrenia pathogenesis
S Li, X Li, J Liu, Y Huo, L Li, J Wang… - American Journal of …, 2021 - Wiley Online Library
Schizophrenia is a severe mental disease characterized with positive symptoms, negative
symptoms, and cognitive impairments. Although recent genome‐wide association studies …
symptoms, and cognitive impairments. Although recent genome‐wide association studies …
Mutations in DISC1 alter IP3R and voltage-gated Ca2+ channel functioning, implications for major mental illness
AR Rittenhouse, S Ortiz-Miranda… - Neuronal …, 2021 - portlandpress.com
Abstract Disrupted in Schizophrenia 1 (DISC1) participates in a wide variety of
developmental processes of central neurons. It also serves critical roles that underlie …
developmental processes of central neurons. It also serves critical roles that underlie …
Variations and expression features of CYP2D6 contribute to schizophrenia risk
Genome-wide association studies (GWAS) have successfully identified 145 loci implicated
in schizophrenia (SCZ). However, the underlying mechanisms remain largely unknown …
in schizophrenia (SCZ). However, the underlying mechanisms remain largely unknown …