The pancreatic islets of Langerhans secrete several hormones critical for glucose
homeostasis. The β-cells, the major cellular component of the pancreatic islets, secrete …

Presynaptic active zone proteins couple calcium influx with synaptic vesicle exocytosis.
However, the control of presynaptic calcium channel localization by active zone proteins is …

Rab-interacting molecule (RIM)-binding protein 2 (BP2) is a multidomain protein of the
presynaptic active zone (AZ). By binding to RIM, bassoon (Bsn), and voltage-gated Ca 2+ …

Rapid and precise neuronal communication is enabled through a highly synchronous
release of signaling molecules neurotransmitters within just milliseconds of the action …

The cellular and molecular mechanisms that drive neurodegeneration remain poorly
defined. Recent clinical trial failures, difficult diagnosis, uncertain etiology, and lack of …

In the malaria vector Anopheles gambiae, two point mutations in the acetylcholinesterase
(ace-1 R) and the sodium channel (kdr R) genes confer resistance to organophosphate …

Neuronal synapses encompass three compartments: presynaptic axon terminal, synaptic
cleft, and postsynaptic dendrite. Each compartment contains densely packed molecular …

The development of functional synapses in the nervous system is important for animal
physiology and behaviors, and its disturbance has been linked with many …

Abstract L-type Ca 2+ channels (LTCCs) are key elements in electromechanical coupling in
striated muscles and formation of neuromuscular junctions (NMJs). However, the …

For decades, a role for the Ca2+-binding protein calmodulin (CaM) in Ca2+-dependent
presynaptic modulation of synaptic transmission has been recognized. Here, we …