The incidence of inflammatory bowel disease (IBD) is rapidly rising throughout the world.
Although tremendous efforts have been made, limited therapeutics are available for IBD …

The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …

As naturally occurring bioactive products, several lines of evidence have shown the potential
of polyphenols in the medical intervention of various diseases, including tumors …

Cartilage-targeting delivery of therapeutic agents is still an effective strategy for osteoarthritis
(OA) therapy. Recently, scavenging for reactive oxygen species (ROS) and activating …

The gastrointestinal tract (GIT) affects not only local diseases in the GIT but also various
systemic diseases. Factors that can affect the health and disease of both GIT and the human …

Although magnolol (Mag), an anti-inflammatory natural compound, has been demonstrated
to play protective effects on ulcerative colitis (UC), its application as an alternative …

Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-
accumulation of ROS causes premature aging and/or death and is associated with various …

Regulation of CRISPR-Cas9 functions in vivo is conducive to developing precise therapeutic
genome editing. Here, we report a CRISPR-Cas9 prodrug nanosystem (termed …

Microorganisms have been extensively applied as active biotherapeutic agents or drug
delivery vehicles for antitumor treatment because of their unparalleled bio-functionalities …

Immunotherapy is known to be clinically beneficial for cancer patients and in many cases
represents the new standard of care. Because of this success, the interest in integrating …