[HTML][HTML] Recent advances and prospects of hyaluronan as a multifunctional therapeutic system

NG Kotla, SR Bonam, S Rasala, J Wankar… - Journal of Controlled …, 2021 - Elsevier
Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG), cell-
surface-associated biopolymer and is the key component of tissue extracellular matrix …

Colon-targeted drug delivery of polysaccharide-based nanocarriers for synergistic treatment of inflammatory bowel disease: A review

M Cui, M Zhang, K Liu - Carbohydrate polymers, 2021 - Elsevier
Drugs such as immunosuppressants and glucocorticoids used for the treatment of
inflammatory bowel disease (IBD) have certain troubling side effects. Polysaccharide-based …

[HTML][HTML] Cyclodextrin-based host-guest complexes loaded with regorafenib for colorectal cancer treatment

H Bai, J Wang, CU Phan, Q Chen, X Hu, G Shao… - Nature …, 2021 - nature.com
The malignancy of colorectal cancer (CRC) is connected with inflammation and tumor-
associated macrophages (TAMs), but effective therapeutics for CRC are limited. To integrate …

Immunomodulatory biomaterials and their application in therapies for chronic inflammation-related diseases

JR Nakkala, Z Li, W Ahmad, K Wang, C Gao - Acta Biomaterialia, 2021 - Elsevier
The degree of tissue injuries such as the level of scarring or organ dysfunction, and the
immune response against them primarily determine the outcome and speed of healing …

Calcium pectinate and hyaluronic acid modified lactoferrin nanoparticles loaded rhein with dual-targeting for ulcerative colitis treatment

R Luo, M Lin, C Fu, J Zhang, Q Chen, C Zhang… - Carbohydrate …, 2021 - Elsevier
Herein, dual-bioresponsive of Rhein (RH) in promoting colonic mucous damage repair and
controlling inflammatory reactions were combined by the dual-targeting (intestinal epithelial …

[HTML][HTML] Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies

P Liu, C Gao, H Chen, CT Vong, X Wu, X Tang… - … Pharmaceutica Sinica B, 2021 - Elsevier
Inflammatory bowel disease (IBD) is a chronic intestinal disease with painful clinical
manifestations and high risks of cancerization. With no curative therapy for IBD at present …

[HTML][HTML] Improved functionality of Ligilactobacillus salivarius Li01 in alleviating colonic inflammation by layer-by-layer microencapsulation

M Yao, Y Lu, T Zhang, J Xie, S Han, S Zhang… - npj Biofilms and …, 2021 - nature.com
The low viability during gastrointestinal transit and poor mucoadhesion considerably limits
the effectiveness of Ligilactobacillus salivarius Li01 (Li01) in regulating gut microbiota and …

Site‐specific biomimicry of Antioxidative melanin formation and its application for acute liver injury therapy and imaging

C Zhao, Z Li, J Chen, L Su, J Wang… - Advanced …, 2021 - Wiley Online Library
Biocompatible nano‐antioxidants composed of natural molecules/materials, such as
dopamine and melanin, are of great interest for diverse biomedical applications. However …

Immunomodulatory nanosystems for treating inflammatory diseases

N Ahamad, A Kar, S Mehta, M Dewani, V Ravichandran… - Biomaterials, 2021 - Elsevier
Inflammatory disease (ID) is an umbrella term encompassing all illnesses involving chronic
inflammation as the central manifestation of pathogenesis. These include, inflammatory …

[HTML][HTML] Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide …

XW Xiang, HZ Zheng, R Wang, H Chen, JX Xiao… - Marine Drugs, 2021 - mdpi.com
The intestinal flora is recognized as a significant contributor to the immune system. In this
research, the protective effects of oyster peptides on immune regulation and intestinal …