Engineering thermophilic Geobacillus thermoglucosidasius for riboflavin production

Z Yang, Q Sun, G Tan, Q Zhang, Z Wang… - Microbial …, 2021 - Wiley Online Library
The potential advantages for fermentation production of chemicals at high temperatures are
attractive, such as promoting the rate of biochemical reactions, reducing the risk of …

Strategies to increase the production of biosynthetic riboflavin

G Zhao, F Dong, X Lao, H Zheng - Molecular Biotechnology, 2021 - Springer
Riboflavin is widely regarded as an essential nutrient that is involved in biological oxidation
in vivo. In addition to preventing and treating acyl-CoA dehydrogenase deficiency in patients …

Temperature and pH dual-responsive supramolecular hydrogels based on riboflavin sodium phosphate and 2, 6-Diaminopurine with thixotropic and fluorescent …

G Feng, S Zhang, S Zhong, M Tan, Y Yang… - Colloids and Surfaces A …, 2021 - Elsevier
A novel temperature and pH dual-responsive supramolecular (TPS) hydrogels based on
riboflavin sodium phosphate (RP) and 2, 6-Diaminopurine (DAP) were fabricated and …

Improving the Production of Riboflavin by Introducing a Mutant Ribulose 5-Phosphate 3-Epimerase Gene in Bacillus subtilis

B Yang, Y Sun, S Fu, M Xia, Y Su, C Liu… - … in Bioengineering and …, 2021 - frontiersin.org
Ribulose 5-phosphate (Ru5P) and guanosine 5′-triphosphate (GTP) are two key
precursors of riboflavin, whereby Ru5P is also a precursor of GTP. Ribulose 5-phosphate 3 …

Enhancement of riboflavin production in Bacillus subtilis via in vitro and in vivo metabolic engineering of pentose phosphate pathway

M Zhang, X Zhao, X Chen, M Li, X Wang - Biotechnology Letters, 2021 - Springer
Objectives The production of riboflavin with Bacillus subtilis, is an established process,
however it is yet to be fully optimized. The aim of this study was to explore how riboflavin …

Effects of sirtuins on the riboflavin production in Ashbya gossypii

T Kato, J Azegami, M Kano, HA El Enshasy… - Applied Microbiology and …, 2021 - Springer
This study focuses on sirtuins, which catalyze the reaction of NAD+-dependent protein
deacetylase, for riboflavin production in A. gossypii. Nicotinamide, a known inhibitor of …

New Promoters for Metabolic Engineering of Ashbya gossypii

G Muñoz-Fernández, JF Montero-Bullón, JL Revuelta… - Journal of Fungi, 2021 - mdpi.com
Ashbya gossypii is a filamentous fungus that is currently exploited for the industrial
production of riboflavin. In addition, metabolically engineered strains of A. gossypii have …

Riboflavin inhibits histamine-dependent itch by modulating transient receptor potential Vanilloid 1 (TRPV1)

K Lee, YI Choi, ST Im, SM Hwang, HK Lee… - Frontiers in Molecular …, 2021 - frontiersin.org
Riboflavin, also known as vitamin B2, isfound in foods and is used as a dietary supplement.
Its deficiency (also called ariboflavinosis) results in some skin lesions and inflammations …

Multiple copies of the oxytetracycline gene cluster in selected Streptomyces rimosus strains can provide significantly increased titers

Š Pikl, AF Carrillo Rincón, L Slemc, D Goranovič… - Microbial Cell …, 2021 - Springer
Background Natural products are a valuable source of biologically active compounds that
have applications in medicine and agriculture. One disadvantage with natural products is …

Overexpression of Riboflavin Excretase Enhances Riboflavin Production in the Yeast Candida famata

AO Tsyrulnyk, DV Fedorovych, KV Dmytruk… - … : Methods and Protocols, 2021 - Springer
Many microorganisms are capable of riboflavin oversynthesis and accumulation in a
medium, suggesting that they efficiently excrete riboflavin. The mechanisms of riboflavin …