DNA methylation differences in cortical grey and white matter in schizophrenia

A Berdenis van Berlekom, N Notman… - …, 2021 - Taylor & Francis
Aim: Identify grey-and white-matter-specific DNA-methylation differences between
schizophrenia (SCZ) patients and controls in postmortem brain cortical tissue. Materials & …

Novel DNA methylation marker discovery by assumption‐free genome‐wide association analysis of cognitive function in twins

A Mohammadnejad, M Soerensen, J Baumbach… - Aging …, 2021 - Wiley Online Library
Privileged by rapid increase in available epigenomic data, epigenome‐wide association
studies (EWAS) are to make a profound contribution to understand the molecular …

Plasma cell-free DNA methylomics of bipolar disorder with and without rapid cycling

AMC Ho, SJ Winham, BM McCauley… - Frontiers in …, 2021 - frontiersin.org
Rapid cycling (RC) burdens bipolar disorder (BD) patients further by causing more severe
disability and increased suicidality. Because diagnosing RC can be challenging, RC …

A validation of Illumina EPIC array system with bisulfite-based amplicon sequencing

AJ Noble, JF Pearson, JM Boden, LJ Horwood… - PeerJ, 2021 - peerj.com
Abstract The Illumina Infinium® MethylationEPIC BeadChip system (hereafter EPIC array) is
considered to be the current gold standard detection method for assessing DNA methylation …

Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation

KC de Oliveira, C Camilo, VD Gastaldi… - BMC genomic data, 2021 - Springer
Background Obsessive-compulsive disorder (OCD) is characterized by intrusive thoughts
and repetitive actions, that presents the involvement of the cortico-striatal areas. The …

Survival time prediction of breast cancer patients using feature selection algorithm crystall

S Liu, H Li, Q Zheng, L Yang, M Duan, X Feng… - IEEE …, 2021 - ieeexplore.ieee.org
Breast cancer is one of main causes of death for women. Most of the existing survival
analyses focus on the features' associations with whether the patients may survive five years …

Genome-wide study of DNA methylation in amyotrophic lateral sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol …

PJ Hop, RAJ Zwamborn, E Hannon, GL Shireby… - medRxiv, 2021 - medrxiv.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability of around 50%. DNA methylation patterns can serve as biomarkers of (past) …

Associations between an integrated component of maternal glycemic regulation in pregnancy and cord blood DNA methylation

DL Juvinao-Quintero, A Cardenas, P Perron… - …, 2021 - Taylor & Francis
Background: Previous studies suggest that fetal programming to hyperglycemia in
pregnancy is due to modulation of DNA methylation (DNAm), but they have been limited in …

Comparative epigenome-wide analysis highlights placenta-specific differentially methylated regions

M Groleau, F White, A Cardenas, P Perron… - …, 2021 - Taylor & Francis
Aim: The placenta undergoes DNA methylation (DNAm) programming that is unique
compared with all other fetal tissues. We aim to decipher some of the physiologic roles of the …

Differential DNA methylation in prostate tumors from Puerto Rican men

G Ruiz-Deya, J Matta, J Encarnación-Medina… - International journal of …, 2021 - mdpi.com
In 2020, approximately 191,930 new prostate cancer (PCa) cases are estimated in the
United States (US). Hispanic/Latinos (H/L) are the second largest racial/ethnic group in the …