Autophagy is a highly conserved catabolic process and a major cellular pathway for the
degradation of long-lived proteins and cytoplasmic organelles. An increasing body of …

Cardiovascular diseases (CVDs) are one of the leading causes of the most considerable
mortality globally, and it has been tried to find the molecular mechanisms and design new …

Extracellular vesicles (EVs) transfer functional molecules between cells. CD63 is a widely
recognized EV marker that contributes to EV secretion from cells. However, the regulation of …

Alzheimer disease (AD) is the most prevalent neurodegenerative disorder leading to
dementia in the elderly. Unfortunately, no cure for AD is available to date. Increasing …

Age-related macular degeneration (AMD) is a common irreversible ocular disease
characterized by vision impairment among older people. Many risk factors are related to …

Autophagy is a highly dynamic and multi-step process, regulated by many functional protein
units. Here, we have built up a comprehensive and up-to-date annotated gene list for the …

Macroautophagy/autophagy plays an important role during the development of human
cancer. BECN1 (beclin 1), a core player in autophagy regulation, is downregulated in many …

Abstract PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism
for mammalian enzyme-related receptors in transducing signals or biological processes …

There is an urgent need to identify therapies that prevent SARS-CoV-2 infection and
improve the outcome of COVID-19 patients. Although repurposed drugs with favorable …

As a populous country, China has always attached importance to the protection of cultivated
land and food security. However, in the process of promoting rural development, agricultural …