Monoallelic expression of a single gene family member underpins a molecular “arms race”
between many pathogens and their host, through host monoallelic immunoglobulin and …

DEAD-box RNA helicases are ubiquitous proteins found in all kingdoms of life and that are
associated with all processes involving RNA. Their central roles in biology make these …

All trypanosomatid genomes are colonized by non-LTR retrotransposons which exhibit a
highly conserved 77-nt sequence at their 5′ ends, known as the Pr77-hallmark (Pr77). The …

The protozoan parasite Trypanosoma brucei causes human African trypanosomiasis (HAT),
a fatal and neglected disease in the tropic areas. Owing to the scarcity of investments, new …

The single mitochondrial nucleoid (kinetoplast) of Trypanosoma brucei is found proximal to
a basal body (mature (mBB)/probasal body (pBB) pair). Kinetoplast inheritance requires …

This chapter provides state‐of‐the‐art information to the reader with an overview on the
trends, advances, and perspectives in vaccines and vaccinology against fastidious …

Trypanosoma brucei gambiense, an extracellular protozoan parasite, is the primary
causative agent of human African Trypanosomiasis. T. b. gambiense is endemic to West and …

Trypanosoma brucei is the causative agent of human sleeping sickness. The parasites'
variant surface glycoprotein (VSG) enables them to evade adaptive immunity via antigenic …

Background Faithful DNA replication is essential to maintain genomic stability in all living
organisms, and the regulatory pathway for DNA replication initiation is conserved from yeast …

Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi. Symptoms of the
chronic disease occur decades after infection in about 30% of the infected people. The …