Structural studies of the shortest extended synaptotagmin with only two C2 domains from Trypanosoma brucei
E Stepinac, N Landrein, D Skwarzyńska, P Wójcik… - Iscience, 2021 - cell.com
Extended synaptotagmins (E-Syts) localize at membrane contact sites between the
endoplasmic reticulum (ER) and the plasma membrane to mediate inter-membrane lipid …
endoplasmic reticulum (ER) and the plasma membrane to mediate inter-membrane lipid …
Anti-trypanosomal potential of the red sea soft coral nephthea mollis supported by metabolomic profiling and molecular docking studies
The total ethanol extract and its derived ethyl acetate fraction of the soft coral Nephthea
mollis displayed remarkable in-vitro anti-trypanosomal potential against Trypanosoma …
mollis displayed remarkable in-vitro anti-trypanosomal potential against Trypanosoma …
Nucleolar targeting in an early-branching eukaryote suggests a general physicochemical mechanism for ribosome protein sorting
The eukaryotic cell targets proteins to the organelles in which they function, both membrane-
bound (like the nucleus) and non-membrane-bound (like the nucleolus). Nucleolar targeting …
bound (like the nucleus) and non-membrane-bound (like the nucleolus). Nucleolar targeting …
From the origin and molecular diversity of the amastins, to the origin and diversity of intracellular parasitism from human Trypanosomatids
A Padilla - bioRxiv, 2021 - biorxiv.org
The large families of amastins from Leishmania donovani, L. infantum, L. major, L.
braziliensis and Trypanosoma cruzi are strongly associated with the evolution of intracellular …
braziliensis and Trypanosoma cruzi are strongly associated with the evolution of intracellular …
Trypanosome morphogenesis involves recruitment of a pleckstrin homology domain protein by an orphan kinesin to the microtubule quartet
C Benz, N Müller, M Vancová, S Kaltenbrunner… - bioRxiv, 2021 - biorxiv.org
Kinesins are motor proteins found in all eukaryotic lineages that move along microtubule
tracks to mediate numerous cellular processes such as mitosis and intracellular transport of …
tracks to mediate numerous cellular processes such as mitosis and intracellular transport of …
Thiol-Disulphide Redox Signalling/Control during the Life Cycle of Pathogenic Trypanosomatids
G Specker, L Piacenza, R Radi… - Redox Regulation of …, 2021 - taylorfrancis.com
Trypanosomatids are ancient unicellular eukaryotes that parasitize different invertebrates
and mammals, producing deadly diseases and economic losses. During their complex life …
and mammals, producing deadly diseases and economic losses. During their complex life …
NMR structure and dynamics of Q4DY78, a conserved kinetoplasid-specific protein from Trypanosoma cruzi
ÉD D'Andréa, JS Retel, A Diehl, P Schmieder… - Journal of Structural …, 2021 - Elsevier
The 106-residue protein Q4DY78 (UniProt accession number) from Trypanosoma cruzi is
highly conserved in the related kinetoplastid pathogens Trypanosoma brucei and …
highly conserved in the related kinetoplastid pathogens Trypanosoma brucei and …
Dealing with Multiple Environments: The Challenges of the Trypanosome Lifecycle
E Calvo Alvarez, P Bastin - Systematics and the Exploration of …, 2021 - Wiley Online Library
African trypanosomes (Trypanosoma genus) are unicellular parasites responsible for
infectious diseases that affect humans and animals. Human African trypanosomiasis is …
infectious diseases that affect humans and animals. Human African trypanosomiasis is …
Actin-based myosin XXI (13) molecular motor is involved in early phase of Leishmania cytokinesis
R Bajaj, CM Gupta - bioRxiv, 2021 - biorxiv.org
Leishmania genome encodes for two isoforms of myosin, but only Myosin XXI (Myo21),
which is a novel form of myosin in that it contains two ubiquitin associated-like (UBA) …
which is a novel form of myosin in that it contains two ubiquitin associated-like (UBA) …
Design and synthesis of novel P. fulciparum GDH inhibitors for use as potential antimalarial agents
EK Kasonde - 2021 - repository.londonmet.ac.uk
Malaria is a potentially fatal parasitic disease that is endemic in 109 countries and threatens
over 2.4 billion people, representing 40% of the global population. While there has been a …
over 2.4 billion people, representing 40% of the global population. While there has been a …