IDH-wildtype lower-grade diffuse gliomas: the importance of histological grade and molecular assessment for prognostic stratification
G Berzero, AL Di Stefano, S Ronchi, F Bielle… - Neuro …, 2021 - academic.oup.com
Background Isocitrate dehydrogenase (IDH) wildtype (wt) grade II gliomas are a rare and
heterogeneous entity. Survival and prognostic factors are poorly defined. Methods We …
heterogeneous entity. Survival and prognostic factors are poorly defined. Methods We …
TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma
K Fujimoto, H Arita, K Satomi, K Yamasaki… - Acta …, 2021 - Springer
Abstract The Consortium to Inform Molecular and Practical Approaches to CNS Tumor
Taxonomy (cIMPACT-NOW) update 3 recommends that histologic grade II and III IDH …
Taxonomy (cIMPACT-NOW) update 3 recommends that histologic grade II and III IDH …
Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis
Diffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis
compared to IDH-wildtype malignant gliomas. Acquired mismatch repair deficiency is known …
compared to IDH-wildtype malignant gliomas. Acquired mismatch repair deficiency is known …
The evolving classification of diffuse gliomas: World Health Organization updates for 2021
A Perez, JT Huse - Current neurology and neuroscience reports, 2021 - Springer
Abstract Purpose of Review The upcoming 2021 World Health Organization (WHO)
Classification of Tumours of the Central Nervous System will feature numerous changes in …
Classification of Tumours of the Central Nervous System will feature numerous changes in …
The cIMPACT-NOW updates and their significance to current neuro-oncology practice
LN Gonzalez Castro, P Wesseling - Neuro-Oncology Practice, 2021 - academic.oup.com
Over the past 4 years, advances in molecular pathology have enhanced our understanding
of CNS tumors, providing new elements to refine their classification and improve the 2016 …
of CNS tumors, providing new elements to refine their classification and improve the 2016 …
Phenotypic mapping of pathologic cross-talk between glioblastoma and innate immune cells by synthetic genetic tracing
Glioblastoma is a lethal brain tumor that exhibits heterogeneity and resistance to therapy.
Our understanding of tumor homeostasis is limited by a lack of genetic tools to selectively …
Our understanding of tumor homeostasis is limited by a lack of genetic tools to selectively …
[HTML][HTML] Uncovering spatiotemporal heterogeneity of high-grade gliomas: From disease biology to therapeutic implications
Glioblastomas (GBM) are the most common and aggressive tumors of the central nervous
system. Rapid tumor growth and diffuse infiltration into healthy brain tissue, along with high …
system. Rapid tumor growth and diffuse infiltration into healthy brain tissue, along with high …
[HTML][HTML] Deep neural network analysis of pathology images with integrated molecular data for enhanced glioma classification and grading
Gliomas are primary brain tumors that originate from glial cells. Classification and grading of
these tumors is critical to prognosis and treatment planning. The current criteria for glioma …
these tumors is critical to prognosis and treatment planning. The current criteria for glioma …
WHO classification of tumors of the nervous system: preview of the upcoming 5th edition
EJ Rushing - memo-Magazine of European Medical Oncology, 2021 - Springer
Identification of the underlying genetic and epigenetic alterations in an increasing number of
tumors of the nervous system is contributing to a more clinically relevant classification. In the …
tumors of the nervous system is contributing to a more clinically relevant classification. In the …
[HTML][HTML] Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma
Objective: O6methylguanine-DNA methyltransferase (MGMT) promoter methylation is a
biomarker widely used to predict the sensitivity of IDH-wildtype glioblastoma to …
biomarker widely used to predict the sensitivity of IDH-wildtype glioblastoma to …