Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

K Zhang, L Miorin, T Makio, I Dehghan, S Gao… - Science …, 2021 - science.org
The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2
outbreak worldwide has highlighted the need for understanding viral-host interactions …

Blockchain applications in health care for COVID-19 and beyond: a systematic review

WY Ng, TE Tan, PVH Movva, AHS Fang… - The Lancet Digital …, 2021 - thelancet.com
The COVID-19 pandemic has had a substantial and global impact on health care, and has
greatly accelerated the adoption of digital technology. One of these emerging digital …

SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

DW Sanders, CC Jumper, PJ Ackerman, D Bracha… - Elife, 2021 - elifesciences.org
Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …

Peptide-like and small-molecule inhibitors against Covid-19

S Pant, M Singh, V Ravichandiran… - Journal of …, 2021 - Taylor & Francis
Coronavirus disease strain (SARS-CoV-2) was discovered in 2019, and it is spreading very
fast around the world causing the disease Covid-19. Currently, more than 1.6 million …

Virus-host interactome and proteomic survey reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

J Li, M Guo, X Tian, X Wang, X Yang, P Wu, C Liu… - Med, 2021 - cell.com
Background The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a global public health …

[HTML][HTML] In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs

L Sun, P Li, X Ju, J Rao, W Huang, L Ren, S Zhang… - Cell, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic. Understanding of the RNA virus and its …

SARS-CoV-2 antiviral therapy

K Tao, PL Tzou, J Nouhin, H Bonilla… - Clinical microbiology …, 2021 - Am Soc Microbiol
The development of effective antiviral therapy for COVID-19 is critical for those awaiting
vaccination, as well as for those who do not respond robustly to vaccination. This review …

[HTML][HTML] METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection

N Li, H Hui, B Bray, GM Gonzalez, M Zeller… - Cell reports, 2021 - cell.com
It is urgent and important to understand the relationship of the widespread severe acute
respiratory syndrome coronavirus clade 2 (SARS-CoV-2) with host immune response and …

[HTML][HTML] COVID-19 vaccination for people with severe mental illness: why, what, and how?

V Mazereel, K Van Assche, J Detraux… - The Lancet …, 2021 - thelancet.com
Psychiatric disorders, and especially severe mental illness, are associated with an
increased risk of severe acute respiratory syndrome coronavirus 2 infection and COVID-19 …

Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection

JT Jan, TJR Cheng, YP Juang, HH Ma… - Proceedings of the …, 2021 - National Acad Sciences
The outbreak of COVID-19 caused by SARS-CoV-2 has resulted in more than 50 million
confirmed cases and over 1 million deaths worldwide as of November 2020. Currently, there …