Depression is a world-wide psychological disease and millions of people suffer from it. The
illness is basically characterized by low mood with some other diverse manifestations. The …

Depression is a neurological disorder that can affect any individual and manifests symptoms
liNe prolonged periods of low moods and loss of appetite. The high incidence and suicide …

Background Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in the synthetic
pathway for brain serotonin and is considered key factor for maintaining normal serotonin …

Importance of the field: Serotonin (5-HT) has been implicated in several psychiatric
disorders including schizophrenia, depressive disorder and suicide. The key and rate …

BACKGROUND: Serotonin (5-HT) has been implicated in the pathophysiology of several
psychiatric disorders including major depression (MD). Tryptophan hydroxylase (TPH) is the …

Impaired brain serotonin neurotransmission is a potential component of the diathesis of
major depression. Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic …

BACKGROUND: Tryptophan hydroxylases (TPHs) are involved in the biosynthesis of
serotonin and are therefore candidate genes for psychiatric disorders, including depression …

Tryptophan catabolites pathway disorders are observed in patients with depression.
Moreover, single nucleotide polymorphisms of tryptophan hydroxylase genes may modulate …

DU, Jing et al. Association study of the TPH2 Gene with Major Depressive Disorder in the
Han Chinese Population. Eur. J. Psychiat.[online]. 2016, vol. 30, n. 2, pp. 131-140. ISSN …

Based on genetic variation, there is accumulating evidence that altered function of
tryptophan hydroxylase-2 (TPH2), the enzyme critical for synthesis of serotonin (5-HT) in the …