[HTML][HTML] Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis

T Su, Y Yang, S Lai, J Jeong, Y Jung… - Cellular and molecular …, 2021 - Elsevier
Background Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the
progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here …

The evolving role of liver sinusoidal endothelial cells in liver health and disease

MJ McConnell, E Kostallari, SH Ibrahim, Y Iwakiri - Hepatology, 2023 - journals.lww.com
LSECs are a unique population of endothelial cells within the liver and are recognized as
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …

Role of liver sinusoidal endothelial cells in liver diseases

J Gracia-Sancho, E Caparrós… - Nature reviews …, 2021 - nature.com
Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization

W de Haan, C Øie, M Benkheil… - American Journal …, 2020 - journals.physiology.org
Liver sinusoidal endothelial cells (LSECs) are the first liver cells to encounter waste
macromolecules, pathogens, and toxins in blood. LSECs are highly specialized to mediate …

[HTML][HTML] Prominent receptors of liver sinusoidal endothelial cells in liver homeostasis and disease

E Pandey, AS Nour, EN Harris - Frontiers in physiology, 2020 - frontiersin.org
Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal cells
lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with …

[HTML][HTML] Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo

PF Lalor, WK Lai, SM Curbishley, S Shetty… - World journal of …, 2006 - ncbi.nlm.nih.gov
The hepatic sinusoids are lined by a unique population of hepatic sinusoidal endothelial
cells (HSEC), which is one of the first hepatic cell populations to come into contact with …

[PDF][PDF] Liver sinusoidal endothelium: a microenvironmentdependent differentiation program in rat including the novel junctional protein liver endothelial differentiation …

C Géraud, K Schledzewski, A Demory, D Klein… - …, 2010 - Wiley Online Library
Liver sinusoidal endothelium (LSEC) is a prime example of organspecific microvascular
differentiation and functions. Diseaseassociated capillarization of LSEC in vivo and …

Liver sinusoidal endothelial cells (LSECs) modifications in patients with chronic hepatitis C

A Baiocchini, F Del Nonno, C Taibi… - Scientific reports, 2019 - nature.com
The sinusoidal endothelial cells present in the liver (LSECs) are tipically characterized by
the presence of pores (fenestrae). During some pathological conditions LSECs undergo …

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

J Poisson, S Lemoinne, C Boulanger, F Durand… - Journal of …, 2017 - Elsevier
Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells
representing the interface between blood cells on the one side and hepatocytes and hepatic …

[PDF][PDF] Transcriptional dynamics of hepatic sinusoidassociated cells after liver injury

MK Terkelsen, SM Bendixen, D Hansen… - …, 2020 - Wiley Online Library
Background and Aims Hepatic sinusoidal cells are known actors in the fibrogenic response
to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and …