A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex

Z Yao, H Liu, F Xie, S Fischer, RS Adkins, AI Aldridge… - Nature, 2021 - nature.com
Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased
samples of the diverse cell types in the brain,–. With the proliferation of multi-omics datasets …

[HTML][HTML] Phenotypic variation of transcriptomic cell types in mouse motor cortex

F Scala, D Kobak, M Bernabucci, Y Bernaerts… - Nature, 2021 - nature.com
Cortical neurons exhibit extreme diversity in gene expression as well as in morphological
and electrophysiological properties 1, 2. Most existing neural taxonomies are based on …

[HTML][HTML] Spatially resolved cell atlas of the mouse primary motor cortex by MERFISH

M Zhang, SW Eichhorn, B Zingg, Z Yao, K Cotter… - Nature, 2021 - nature.com
A mammalian brain is composed of numerous cell types organized in an intricate manner to
form functional neural circuits. Single-cell RNA sequencing allows systematic identification …

A multimodal cell census and atlas of the mammalian primary motor cortex

Principal manuscript editors, Analysis coordination… - Nature, 2021 - nature.com
Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …

Comparative cellular analysis of motor cortex in human, marmoset and mouse

TE Bakken, NL Jorstad, Q Hu, BB Lake, W Tian… - Nature, 2021 - nature.com
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …

[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

Z Yao, CTJ van Velthoven, M Kunst, M Zhang… - Nature, 2023 - nature.com
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …

Genetic and epigenetic mechanisms contribute to motor neuron pathfinding

K Sharma, AE Leonard, K Lettieri, SL Pfaff - Nature, 2000 - nature.com
Many lines of evidence indicate that genetically distinct subtypes of motor neurons are
specified during development, with each type having characteristic properties of axon …

Brain-wide correspondence of neuronal epigenomics and distant projections

J Zhou, Z Zhang, M Wu, H Liu, Y Pang, A Bartlett… - Nature, 2023 - nature.com
Single-cell analyses parse the brain's billions of neurons into thousands of 'cell-type'clusters
residing in different brain structures. Many cell types mediate their functions through targeted …

Molecularly defined and spatially resolved cell atlas of the whole mouse brain

M Zhang, X Pan, W Jung, AR Halpern, SW Eichhorn… - Nature, 2023 - nature.com
In mammalian brains, millions to billions of cells form complex interaction networks to enable
a wide range of functions. The enormous diversity and intricate organization of cells have …

Epigenomic diversity of cortical projection neurons in the mouse brain

Z Zhang, J Zhou, P Tan, Y Pang, AC Rivkin… - Nature, 2021 - nature.com
Neuronal cell types are classically defined by their molecular properties, anatomy and
functions. Although recent advances in single-cell genomics have led to high-resolution …