Inflammaging, the increase of proinflammatory processes with increasing age, has multiple
mechanisms from increasing numbers of senescent cells secreting cytokines to changes in …

The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Inflammaging is associated with aging-associated cognitive loss and neurodegeneration.
Chronic nonsteroidal anti-inflammatory drug (NSAID) use has been reported to reduce the …

Background A hallmark of aging is the appearance of sustained pro‐inflammatory
responses and reduced clearance of pathogenic materials. Systemically, aging is …

There is increasing evidence from basic science and human epidemiological studies that
inflammation, oxidative stress, and metabolic abnormalities are associated with age-related …

Modest modulation of oxygen intake, either by inducing mild intermittent hypoxia or
hyperoxia appears to induce modest rejuvenative changes in mammals, in part, by …

In the last decade, cognitive frailty has gained great attention from the scientific community. It
is characterized by high inflammation and oxidant state, endocrine and metabolic …

The aging process is driven by interrelated mechanisms that lead to the emergence of
characteristic phenotypes that include changes in body composition, energy production and …

Aging is an important risk factor for the development of many chronic illnesses that increase
functional disability and limit survival, including vascular disease, diabetes and dementia …

Aberrations in neural signaling, converging to and diverging from oxidative metabolism and
blood supply, contribute to the initiation and maintenance of inflammatory responses …