Mucus Plugs in Medium-sized Airways: A Novel Imaging Biomarker for Phenotyping Chronic
Obstructive Pulmonary Disease subgroups, some genes did exhibit opposing expression …

Based on the trend of personalized medicine, approaches to specific phenotypes in asthma
and COPD are being extensively investigated. Mucus overproduction due to mucus gland …

Autopsy studies in fatal asthma have clearly documented the central role of airway plugging
with pathologic mucus in the pathophysiology of death from asthma, but the role of mucus …

PURPOSE: Luminal mucus plugs (MP) are detected on chest computed tomography (CT) in
up to 67% of individuals with chronic obstructive pulmonary disease (COPD) and are …

BACKGROUND. The link between mucus plugs and airflow obstruction has not been
established in chronic severe asthma, and the role of eosinophils and their products in …

Rationale: Cross-sectional analysis of mucus plugs in computed tomography (CT) lung
scans in the Severe Asthma Research Program (SARP)-3 showed a high mucus plug …

Findings in murine models implicate subpopulations of alveolar macrophages in the
pathogenesis of lung injury and fibrosis; however, the relevance of these findings for …

Airway mucus plugs are identified on computed tomography (CT) images in 41 to 67% of
patients with COPD and associated with increased all-cause mortality (1, 2). Frequent …

Background Mucus plugs have been described in the airways of asthmatic subjects,
particularly those with associated with type 2 inflammation and sputum eosinophilia. In the …

Microvesicles (MVs) released from almost all cells are recognized as cell communication
tools. MVs have been investigated in several inflammatory diseases but poorly in biological …