Diisopropylfluorophosphate (DFP), an organophosphate nerve agent (OPNA), exposure
causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective …

Acute organophosphate (OP) toxicity poses a significant threat to both military and civilian
personnel as it can lead to a variety of cholinergic symptoms including the development of …

Organophosphate pesticides and nerve agents (OPs), are characterized by cholinesterase
inhibition. In addition to severe peripheral symptoms, high doses of OPs can lead to seizures …

Similar to organophosphate (OP) nerve agents, diisopropylfluorophosphate (DFP) rapidly
and irreversibly inhibits acetylcholinesterase, leading to convulsions that can progress to …

Chemical nerve agents (CNA) are increasingly becoming a threat to both civilians and
military personnel. CNA-induced acute effects on the nervous system have been known for …

Organophosphate (OP) nerve agents and pesticides are a class of neurotoxic compounds
that can cause status epilepticus (SE), and death following acute high-dose exposures …

Nerve agents and some pesticides such as diisopropylfluorophosphate (DFP) cause
neurotoxic manifestations that include seizures and status epilepticus (SE), which are …

The increasing number of cases involving the use of nerve agents as deadly weapons has
spurred investigation into the molecular mechanisms underlying nerve agent-induced …

Sex differences are common in human epilepsy. Although men are more susceptible to
seizure than women, the mechanisms underlying sex-specific vulnerabilities to seizure are …

Prolonged seizure activity or status epilepticus (SE) is one of the most critical manifestations
of organophosphate exposure. Previous studies in our laboratory have demonstrated that …