Highly selective gene expression is a key requirement for antigenic variation in several
pathogens, allowing evasion of host immune responses and maintenance of persistent …

Many evolutionarily distant pathogenic organisms have evolved similar survival strategies to
evade the immune responses of their hosts. These include antigenic variation, through …

Antigenic variation as a strategy to evade the host adaptive immune response has evolved
in divergent pathogens. Antigenic variation involves restricted, and often mutually exclusive …

African trypanosomes escape the host adaptive immune response by switching their dense
protective coat of Variant Surface Glycoprotein (VSG). Each cell expresses only one VSG …

Trypanosomes are eukaryotic, unicellular parasites, such as Trypanosoma brucei, which
causes sleeping sickness, and Trypanosoma cruzi, which causes Chagas disease …

Antigenic variation is an immune evasion strategy that has evolved in viral, bacterial and
protistan pathogens. In the African trypanosome this involves stochastic switches in the …

We have discovered a new mechanism of monoallelic gene expression that links antigenic
variation, cell cycle, and development in the model parasite Trypanosoma brucei. African …

The African trypanosome Trypanosoma brucei is a flagellated unicellular parasite
transmitted by tsetse flies that causes African sleeping sickness in sub-Saharan Africa …

African trypanosomes evade humoral immunity through antigenic variation whereby, they
switch expression of the variant surface glycoprotein (VSG) gene encoding their …

African trypanosomes are lethal human and animal parasites that use antigenic variation for
evasion of host adaptive immunity. To facilitate antigenic variation, trypanosomes dedicate …