Epilepsy is a neurological disorder characterized by periods of spontaneous and excessive
brain activity. It affects 65 million people worldwide, and despite the available therapies, 30 …

Epilepsy is the third most common chronic neurological condition worldwide and is currently
considered a growing cause of morbidity and mortality. It mainly consists of spontaneous …

Background: While the NOD-Like Receptor Protein-3 (NLRP3) inflammasome is involved in
a variety of nervous system diseases, its role in epilepsy still needs to be further …

Background Temporal lobe epilepsy (TLE) is often characterized pathologically by severe
neuronal loss in the hippocampus. Understanding the mechanisms of neuron death is key to …

Approximately 50 million people worldwide have epilepsy. In the last decade, several
studies demonstrated that the production of inflammatory mediators (cytokines) by activated …

Neuroinflammation represents a dynamic process of defense and protection against the
harmful action of infectious agents or other detrimental stimuli in the central nervous system …

Epilepsy is a prevalent neurological disorder that affects 65 million people worldwide,
according to the World Health Organization. It is characterized by the occurrence of seizures …

Inflammation plays a role in the pathophysiology of mesial temporal lobe epilepsy (MTLE).
Inflammasome pathways, including the NLRP1 and NLRP3-induced ones, promote …

Epilepsy is one of the most widespread and complex diseases in the central nervous system
(CNS), affecting approximately 65 million people globally, an important factor resulting in …

Microglia and astrocytes are considered the immune cells of the brain. They sense invading
molecules and protect the brain against insults. The most investigated inflammatory cascade …