NLRP3 inflammasome-driven neurodegeneration and epileptiform activity in a model of epileptogenesis in organotypic slices
FJG Meda - 2021 - repositorio.ul.pt
Epilepsy is a neurological disorder characterized by periods of spontaneous and excessive
brain activity. It affects 65 million people worldwide, and despite the available therapies, 30 …
brain activity. It affects 65 million people worldwide, and despite the available therapies, 30 …
Exploring the effect of NLRP3 Inflammasome inhibition in the ex vivo model of epileptogenesis
NMDS Rosa - 2017 - repositorio.ul.pt
Epilepsy is the third most common chronic neurological condition worldwide and is currently
considered a growing cause of morbidity and mortality. It mainly consists of spontaneous …
considered a growing cause of morbidity and mortality. It mainly consists of spontaneous …
NLRP3 inflammasome activation leads to epileptic neurona l apoptosis
K Shen, Q Mao, X Yin, C Zhang, Y Jin… - Current …, 2018 - ingentaconnect.com
Background: While the NOD-Like Receptor Protein-3 (NLRP3) inflammasome is involved in
a variety of nervous system diseases, its role in epilepsy still needs to be further …
a variety of nervous system diseases, its role in epilepsy still needs to be further …
NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model
CC Tan, JG Zhang, MS Tan, H Chen, DW Meng… - Journal of …, 2015 - Springer
Background Temporal lobe epilepsy (TLE) is often characterized pathologically by severe
neuronal loss in the hippocampus. Understanding the mechanisms of neuron death is key to …
neuronal loss in the hippocampus. Understanding the mechanisms of neuron death is key to …
Characterization of cell death in the ex vivo slice model of epileptogenesis
CSB Cavacas - 2017 - repositorio.ul.pt
Approximately 50 million people worldwide have epilepsy. In the last decade, several
studies demonstrated that the production of inflammatory mediators (cytokines) by activated …
studies demonstrated that the production of inflammatory mediators (cytokines) by activated …
The NLRP3 inflammasome in neurodegenerative disorders: insights from epileptic models
L Palumbo, M Carinci, A Guarino, L Asth, S Zucchini… - Biomedicines, 2023 - mdpi.com
Neuroinflammation represents a dynamic process of defense and protection against the
harmful action of infectious agents or other detrimental stimuli in the central nervous system …
harmful action of infectious agents or other detrimental stimuli in the central nervous system …
Exploring the activation of NLRP3 inflammasome by reactive oxygen species (ROS) in a model of epileptogenesis
AMG Godinho - 2021 - repositorio.ul.pt
Epilepsy is a prevalent neurological disorder that affects 65 million people worldwide,
according to the World Health Organization. It is characterized by the occurrence of seizures …
according to the World Health Organization. It is characterized by the occurrence of seizures …
[HTML][HTML] NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and …
EC de Brito Toscano, ÉLM Vieira, BBR Dias, MV Caliari… - Brain Research, 2021 - Elsevier
Inflammation plays a role in the pathophysiology of mesial temporal lobe epilepsy (MTLE).
Inflammasome pathways, including the NLRP1 and NLRP3-induced ones, promote …
Inflammasome pathways, including the NLRP1 and NLRP3-induced ones, promote …
Mechanism of NLRP3 inflammasome in epilepsy and related therapeutic agents
J Chen, Y Gao, N Liu, D Hai, W Wei, Y Liu, X Lan, X Jin… - Neuroscience, 2024 - Elsevier
Epilepsy is one of the most widespread and complex diseases in the central nervous system
(CNS), affecting approximately 65 million people globally, an important factor resulting in …
(CNS), affecting approximately 65 million people globally, an important factor resulting in …
Relevance of astrocytes/microglia communication for NLRP3 signalling in the CNS-proof of concept in an ex vivo epilepsy model
CIC Almeida - 2018 - estudogeral.uc.pt
Microglia and astrocytes are considered the immune cells of the brain. They sense invading
molecules and protect the brain against insults. The most investigated inflammatory cascade …
molecules and protect the brain against insults. The most investigated inflammatory cascade …