Abstract The Consortium to Inform Molecular and Practical Approaches to CNS Tumor
Taxonomy (cIMPACT-NOW) update 3 recommends that histologic grade II and III IDH …

TERT promoter mutations are commonly associated with 1p/19q codeletion in IDH-mutated
gliomas. However, whether these mutations have an impact on patient survival independent …

Background Isocitrate dehydrogenase (IDH) wildtype (wt) grade II gliomas are a rare and
heterogeneous entity. Survival and prognostic factors are poorly defined. Methods We …

EGFR amplification (EGFR amp), the combination of gain of chromosome 7 and loss of
chromosome 10 (7+/10−), and TERT promoter mutation (p TERT mut) are alterations …

Abstract Background The Consortium to Inform Molecular and Practical Approaches to CNS
Tumor Taxonomy (cIMPACT-NOW) has recommended that isocitrate dehydrogenase 1 and …

Mutations in the telomerase reverse transcriptase gene promoter (TERTp) are common in
glioblastomas (GBMs) and oligodendrogliomas (ODGs), and therefore, have a key role in …

Purpose: Diffuse gliomas represent the most prevalent class of primary brain tumor. Despite
significant recent advances in the understanding of glioblastoma [World Health Organization …

Central nervous system tumors are classified based on an integrated diagnosis combining
histology and molecular characteristics, including IDH1/2 and H3‐K27M mutations, as well …

Abstract Background Grade II and III gliomas have variable clinical behaviors, showing the
distinct molecular genetic alterations from glioblastoma (GBM), many of which eventually …

Purpose Histological diagnosis of glioblastoma (GBM) was determined by the presence of
necrosis or microvascular proliferation (histGBM). The 2021 WHO classification now …