Microglial apoptosis is associated with neuroinflammation and no effective strategies are
currently available to protect microglia against inflammation-induced apoptosis. Mouse …

Background The regulation of microglial function via mitochondrial homeostasis is important
in the development of neuroinflammation. The underlying mechanism for this regulatory …

Mitochondrial dysfunction has been found to be associated with neuronal inflammation;
however, no effective drug is available to attenuate neuroinflammation via sustaining …

Background There is a relationship between autophagy and the occurrence, maintenance,
and progression of several neurodegenerative diseases. The activation of microglia after …

Abnormal gene expression, including mRNAs, and microRNAs (miRNA), have been
identified in the development of Alzheimer's disease (AD). Although mitofusin2 (mfn2) has …

Mitochondrial dysfunction increases oxidative stress and depletes ATP in a variety of
disorders. Several antioxidant therapies and drugs affecting mitochondrial biogenesis are …

Mitochondrial dysfunction is associated with the occurrence of a variety of
neurodegenerative diseases, especially Alzheimer disease (AD). As a mitochondrial quality …

Because mitochondrial oxidative stress and impairment are important mediators of neuronal
damage in neurodegenerative diseases and in brain ischemia/reperfusion, in the present …

Alzheimer's disease (AD) is the most common type of dementia that occurs in the elderly.
Amyloid hypothesis is one of the most studied pathological mechanisms, and β-amyloid (Aβ) …

Memory impairment remains a leading disability in survivors of global cerebral ischemia,
occurring secondary to delayed neurodegeneration of hippocampal cornu ammonis-1 (CA1) …