Background Patients with chronic obstructive pulmonary disease (COPD) frequently suffer
from chronic bronchitis (CB) and display steroid-resistant inflammation with increased …

Background Lung inflammation in COPD is poorly controlled by inhaled corticosteroids
(ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those …

Airway epithelium represents the first line of defense against toxic inhalants. In some
subjects, cigarette smoking causes airway inflammation, hypersecretion of mucus, and …

Purpose Cytokines are extracellular signaling proteins that have been widely implicated in
the pathogenesis of chronic obstructive pulmonary disease (COPD). Here, we investigated …

Alveolar macrophages (AMs) represent a unique leukocyte population that responds to
airborne irritants and microbes. This distinct microenvironment coordinates the maturation of …

Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and
mortality. The term is heterogenous and encompasses a number of distinct but often …

Background Inflammation is considered to be of primary pathogenic importance in COPD
but the evidence on which current understanding is based does not distinguish between …

Airway mucus has a key role in protective innate immune responses, but excessive mucus
production and secretion in proximal and in distal airways are associated with disabling …

Lung diseases, such as cystic fibrosis and COPD, are characterized by mucus obstruction
and chronic airway inflammation, but their mechanistic link remains poorly understood …

Background Chronic obstructive pulmonary disease (COPD) is a condition resulting from a
persistent inflammatory state in the airways even after smoking cessation. Intriguingly, the …