Heterogeneity of age-related neural hyperactivity along the CA3 transverse axis
Age-related memory deficits are correlated with neural hyperactivity in the CA3 region of the
hippocampus. Abnormal CA3 hyperactivity in aged rats has been proposed to contribute to …
hippocampus. Abnormal CA3 hyperactivity in aged rats has been proposed to contribute to …
Loss of functional heterogeneity along the CA3 transverse axis in aging
Age-related deficits in pattern separation have been postulated to bias the output of
hippocampal memory processing toward pattern completion, which can cause deficits in …
hippocampal memory processing toward pattern completion, which can cause deficits in …
Age-associated alterations of hippocampal place cells are subregion specific
IA Wilson, S Ikonen, M Gallagher… - Journal of …, 2005 - Soc Neuroscience
Aging is associated with spatial memory impairments and with deficient encoding of
information by the hippocampus. In young adult rats, recent studies on the firing properties of …
information by the hippocampus. In young adult rats, recent studies on the firing properties of …
Altered network timing in the CA3-CA1 circuit of hippocampal slices from aged mice
Network patterns are believed to provide unique temporal contexts for coordinating neuronal
activity within and across different regions of the brain. Some of the characteristics of …
activity within and across different regions of the brain. Some of the characteristics of …
Cognitive aging is associated with redistribution of synaptic weights in the hippocampus
EW Buss, NJ Corbett, JG Roberts… - Proceedings of the …, 2021 - National Acad Sciences
Behaviors that rely on the hippocampus are particularly susceptible to chronological aging,
with many aged animals (including humans) maintaining cognition at a young adult-like …
with many aged animals (including humans) maintaining cognition at a young adult-like …
Combined administration of levetiracetam and valproic acid attenuates age‐related hyperactivity of CA3 place cells, reduces place field area, and increases spatial …
J Robitsek, MH Ratner, T Stewart… - …, 2015 - Wiley Online Library
Learning and memory deficits associated with age‐related mild cognitive impairment have
long been attributed to impaired processing within the hippocampus. Hyperactivity within the …
long been attributed to impaired processing within the hippocampus. Hyperactivity within the …
Transcription of the immediate-early gene Arc in CA1 of the hippocampus reveals activity differences along the proximodistal axis that are attenuated by advanced age
AL Hartzell, SN Burke, LT Hoang, JP Lister… - Journal of …, 2013 - Soc Neuroscience
The CA1 region of the hippocampus receives distinct patterns of afferent input to distal (near
subiculum) and proximal (near CA2) zones. Specifically, distal CA1 receives a direct …
subiculum) and proximal (near CA2) zones. Specifically, distal CA1 receives a direct …
Long-term consolidation of ensemble neural plasticity patterns in hippocampal area CA1
Neural network remodeling underpins the ability to remember life experiences, but little is
known about the long-term plasticity of neural populations. To study how the brain encodes …
known about the long-term plasticity of neural populations. To study how the brain encodes …
Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments
Aged rats display a broad range of behavioral performance in spatial learning. The aim of
this study was to identify candidate genes that are associated with learning and memory …
this study was to identify candidate genes that are associated with learning and memory …
Spatial pattern completion deficits in older adults
Aging may have an impact on the CA3 autoassociative network of the hippocampus, posited
by computational models as supporting pattern completion. Twenty-five young (YAs) and 25 …
by computational models as supporting pattern completion. Twenty-five young (YAs) and 25 …