Collateral density variations are a major determinant of stroke outcome. Here, we explored
the association of missense variants in hypoxia-induced VEGFA/VEGFR2 signaling and …

Vascular endothelial growth factor (VEGF) plays critical roles in angiogenesis and
vasculogenesis, which are associated with post-stroke functional recovery. However, the …

Objectives-Stroke evolves depending on the accumulation of risk factors within the vessel
wall, which leads to atherosclerotic lesions. Vascular endothelial growth factor (VEGF) plays …

Background and Purpose: The purpose of this study was to replicate the top loci associated
with white matter hyperintensity (WMH) phenotypes identified by large genome-wide …

Background: The biologic agents causing leukoaraiosis are unknown. Our aim was to study
the genetic basis of leukoaraiosis. Methods: We analyzed 212 single nucleotide …

Background The immune microenvironment and hypoxia play crucial roles in the
pathophysiology of ischemic stroke (IS). Hence, in this study, we aimed to identify hypoxia …

Objective To examine etiologic stroke subtypes and vascular risk factor profiles and their
association with white matter hyperintensity (WMH) burden in patients hospitalized for acute …

Background Stroke is a major public health burden worldwide. Although genetic variation is
known to play a role in the pathogenesis of stroke, the specific pathogenic mechanisms are …

Objective: To highlight potential functional variants and causal genes for ischemic stroke (IS)
in genomic loci identified by genome-wide association studies (GWAS). Methods: We …

The genetic background of intracranial artery stenosis (ICAS), a major cause of ischemic
stroke, remains elusive. We performed the world's first genome-wide association study …