Missense variants in hypoxia-induced VEGFA/VEGFR2 signaling predict the outcome of large artery atherosclerotic stroke
Z Li, M Wang, J Gu, L Zhao, Y Guo, Z Zhang… - Cellular and Molecular …, 2021 - Springer
Collateral density variations are a major determinant of stroke outcome. Here, we explored
the association of missense variants in hypoxia-induced VEGFA/VEGFR2 signaling and …
the association of missense variants in hypoxia-induced VEGFA/VEGFR2 signaling and …
A functional variant in the 3ˈ-UTR of VEGF predicts the 90-day outcome of ischemic stroke in Chinese patients
J Zhao, Y Bai, L Jin, Y Weng, Y Wang, H Wu, X Li… - PloS one, 2017 - journals.plos.org
Vascular endothelial growth factor (VEGF) plays critical roles in angiogenesis and
vasculogenesis, which are associated with post-stroke functional recovery. However, the …
vasculogenesis, which are associated with post-stroke functional recovery. However, the …
Interaction of the Ile297 variant of vascular endothelial growth factor receptor-2 gene and homocysteine on the risk of stroke recurrence
Objectives-Stroke evolves depending on the accumulation of risk factors within the vessel
wall, which leads to atherosclerotic lesions. Vascular endothelial growth factor (VEGF) plays …
wall, which leads to atherosclerotic lesions. Vascular endothelial growth factor (VEGF) plays …
Replication of top loci from COL4A1/2 associated with white matter hyperintensity burden in patients with ischemic stroke
Background and Purpose: The purpose of this study was to replicate the top loci associated
with white matter hyperintensity (WMH) phenotypes identified by large genome-wide …
with white matter hyperintensity (WMH) phenotypes identified by large genome-wide …
Leukoaraiosis is associated with genes regulating blood–brain barrier homeostasis in ischaemic stroke patients
I Fernandez‐Cadenas, M Mendioroz… - European Journal of …, 2011 - Wiley Online Library
Background: The biologic agents causing leukoaraiosis are unknown. Our aim was to study
the genetic basis of leukoaraiosis. Methods: We analyzed 212 single nucleotide …
the genetic basis of leukoaraiosis. Methods: We analyzed 212 single nucleotide …
Identification of hypoxia-and immune-related biomarkers in patients with ischemic stroke
H Zhang, J Sun, P Zou, Y Huang, Q Yang, Z Zhang… - Heliyon, 2024 - cell.com
Background The immune microenvironment and hypoxia play crucial roles in the
pathophysiology of ischemic stroke (IS). Hence, in this study, we aimed to identify hypoxia …
pathophysiology of ischemic stroke (IS). Hence, in this study, we aimed to identify hypoxia …
White matter hyperintensity burden in acute stroke patients differs by ischemic stroke subtype
AK Giese, MD Schirmer, AV Dalca, R Sridharan… - Neurology, 2020 - AAN Enterprises
Objective To examine etiologic stroke subtypes and vascular risk factor profiles and their
association with white matter hyperintensity (WMH) burden in patients hospitalized for acute …
association with white matter hyperintensity (WMH) burden in patients hospitalized for acute …
Integrative analysis of transcriptome-wide association study and gene expression profiling identifies candidate genes associated with stroke
J Yang, B Yan, Y Fan, L Yang, B Zhao, X He, Q Ma… - PeerJ, 2019 - peerj.com
Background Stroke is a major public health burden worldwide. Although genetic variation is
known to play a role in the pathogenesis of stroke, the specific pathogenic mechanisms are …
known to play a role in the pathogenesis of stroke, the specific pathogenic mechanisms are …
Integrative Analysis Identified IRF6 and NDST1 as Potential Causal Genes for Ischemic Stroke
XB Mo, SF Lei, YH Zhang, H Zhang - Frontiers in Neurology, 2019 - frontiersin.org
Objective: To highlight potential functional variants and causal genes for ischemic stroke (IS)
in genomic loci identified by genome-wide association studies (GWAS). Methods: We …
in genomic loci identified by genome-wide association studies (GWAS). Methods: We …
Genome-wide association study of intracranial artery stenosis followed by phenome-wide association study
The genetic background of intracranial artery stenosis (ICAS), a major cause of ischemic
stroke, remains elusive. We performed the world's first genome-wide association study …
stroke, remains elusive. We performed the world's first genome-wide association study …