Evidence for deficits in behavioural and physiological responses in aged mice relevant to the psychiatric symptom of apathy
MG Jackson, SL Lightman, G Gilmour… - Brain and …, 2021 - journals.sagepub.com
Apathy is widely reported in patients with neurological disorders or post viral infection but is
also seen in otherwise-healthy aged individuals. This study investigated whether aged male …
also seen in otherwise-healthy aged individuals. This study investigated whether aged male …
The battery of tests for experimental behavioral phenotyping of aging animals
YV Gorina, YK Komleva, OL Lopatina… - Advances in …, 2017 - Springer
The purpose of the study was to develop a battery of tests to study social and cognitive
impairments for behavioral phenotyping of aged experimental animals with physiological …
impairments for behavioral phenotyping of aged experimental animals with physiological …
Anxiety and task performance changes in an aging mouse model
ED Nolte, KA Nolte, SSD Yan - Biochemical and biophysical research …, 2019 - Elsevier
Due to the increasing focus on aging as an important risk factor for many serious diseases
and an emphasis on animal models that have translational value, an increasing number of …
and an emphasis on animal models that have translational value, an increasing number of …
Ethological analysis of the senescence-accelerated P/8 mouse
J Brandewiede, M Schachner, F Morellini - Behavioural brain research, 2005 - Elsevier
Behaviour of senescence-accelerated (P/8) and resistant (R/1) mice was assessed using an
ethological approach in a longitudinal study for exploratory and anxiety related behaviours …
ethological approach in a longitudinal study for exploratory and anxiety related behaviours …
[HTML][HTML] Emotional behavior in middle-aged rats: implications for geriatric psychopathologies
M Moretti, AG de Souza, G de Chaves… - Physiology & …, 2011 - Elsevier
Clinical findings reveal that middle-aged patients are more susceptible to suffer from
psychiatric disorders than older ones. However, little is known about the emotional behavior …
psychiatric disorders than older ones. However, little is known about the emotional behavior …
Behavioural and emotional symptoms of apathy are associated with distinct patterns of brain atrophy in neurodegenerative disorders
Apathy is a neurocognitive syndrome of reduced goal-directed behaviour and is an
important cause of disability in neurodegenerative disorders. Frontal–subcortical dysfunction …
important cause of disability in neurodegenerative disorders. Frontal–subcortical dysfunction …
Brain mechanisms underlying apathy
The past few decades have seen growing interest in the neuropsychiatric syndrome of
apathy, conceptualised as a loss of motivation manifesting as a reduction of goal-directed …
apathy, conceptualised as a loss of motivation manifesting as a reduction of goal-directed …
Neural correlates of apathy in patients with neurodegenerative disorders, acquired brain injury, and psychiatric disorders
Apathy can be described as a loss of goal-directed purposeful behavior and is common in a
variety of neurological and psychiatric disorders. Although previous studies investigated …
variety of neurological and psychiatric disorders. Although previous studies investigated …
[HTML][HTML] Age-related changes in species-typical behaviours in the 5xFAD mouse model of Alzheimer's disease from 4 to 16 months of age
TP O'Leary, RE Brown - Behavioural Brain Research, 2024 - Elsevier
Alzheimer's disease (AD) patients show age-related decreases in the ability to perform
activities of daily living and the decline in these activities is related to the severity of …
activities of daily living and the decline in these activities is related to the severity of …
Characterization of apathy-like behaviors in the 5xFAD mouse model of Alzheimer's disease
R Keszycki, G Rodriguez, JT Dunn, A Locci… - Neurobiology of …, 2023 - Elsevier
Most patients with Alzheimer's disease (AD) develop neuropsychiatric symptoms (NPS)
alongside cognitive decline, and apathy is one of the most common symptoms. Few …
alongside cognitive decline, and apathy is one of the most common symptoms. Few …