The brain has a high energy demand but little to no energy stores. Therefore, proper brain
function relies on the delivery of glucose and oxygen by the cerebral vasculature. The …

Increasing evidence from epidemiological, clinical, and experimental studies indicates that
cerebromicrovascular dysfunction and microcirculatory damage play critical roles in the …

Age-related blood-brain barrier (BBB) disruption and cerebromicrovascular rarefaction
contribute importantly to the pathogenesis of both vascular cognitive impairment and …

Connections between various cell types in the brain enable cognitive function. The
neurovascular unit is a structure composed of different cell types that regulate neurovascular …

Preclinical studies provide strong evidence that age-related impairment of neurovascular
coupling (NVC) plays a causal role in the pathogenesis of vascular cognitive impairment …

The cerebral microvasculature consists of pial vascular networks, parenchymal descending
arterioles, ascending venules and parenchymal capillaries. This vascular …

Optical imaging techniques reflect different biochemical processes in the brain, which is
closely related with neural activity. Scientists and clinicians employ a variety of optical …

Cerebral hemodynamics are modulated in response to changes in neuronal activity, a
process termed neurovascular coupling (NVC), which can be disrupted by neuropsychiatric …

Neuronal activation is often accompanied by the regulation of cerebral hemodynamics via a
process known as neurovascular coupling (NVC) which is essential for proper brain function …

Functional magnetic resonance imaging (fMRI) has allowed the noninvasive study of task-
based and resting-state brain dynamics in humans by inferring neural activity from blood …