Human alpha-1 antitrypsin (hAAT) is a versatile protease inhibitor, but little is known about
its targets in the aldosterone-sensitive distal nephron and its role in electrolyte balance and …

Hypertension may develop before or after the onset of diabetes and it is known to increase
the risk of developing diabetic nephropathy. Alpha-1 antitrypsin (AAT) is a multi-functional …

Atrial natriuretic peptide (ANP), a peptide hormone produced by the heart, exerts a chronic
hypotensive effect. Knockout mice with a homozygous disruption of the pro-ANP gene (−/−) …

Atrial Natriuretic Peptide (ANP) exerts a chronic hypotensive effect which is mediated by a
reduction in total peripheral resistance (TPR). Mice with a homozygous disruption of the pro …

Recent findings in atrial natriuretic peptide (ANP) transgenic and gene knockout mouse
models uncovered a tonic vasodilatory effect of this hormone that contributes to chronic …

Background Although it has been well established that atrial natriuretic peptide gene-
disrupted (ANP−/−) mice are a useful model of salt-sensitive hypertension, surprisingly little …

Melo, Luis G., Mark E. Steinhelper, Stephen C. Pang, Yat Tse, and Uwe Ackermann. ANP in
the regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse …

Objective: The proximal tubules of the kidney play a critical role in maintaining normal body
salt and fluid balance and blood pressure homeostasis in part by interactions between two …

Endothelial barrier dysfunction is a hallmark of many severe pathologies, including sepsis or
atherosclerosis. The cardiovascular hormone atrial natriuretic peptide (ANP) has …

Atrial natriuretic peptide (ANP) is a cardiac hormone belonging to the family of natriuretic
peptides (NPs). ANP exerts diuretic, natriuretic, and vasodilatory effects that contribute to …