Microscopic quantification of oxygen consumption across cortical layers
P Mächler, N Fomin-Thunemann, M Thunemann… - bioRxiv, 2021 - biorxiv.org
The cerebral cortex is organized in cortical layers that differ in their cellular density,
composition, and wiring. Cortical laminar architecture is also readily revealed by staining for …
composition, and wiring. Cortical laminar architecture is also readily revealed by staining for …
Baseline oxygen consumption decreases with cortical depth
P Mächler, N Fomin-Thunemann, M Thunemann… - PLoS …, 2022 - journals.plos.org
The cerebral cortex is organized in cortical layers that differ in their cellular density,
composition, and wiring. Cortical laminar architecture is also readily revealed by staining for …
composition, and wiring. Cortical laminar architecture is also readily revealed by staining for …
Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism
R Buxton - Frontiers in neuroenergetics, 2010 - frontiersin.org
Functional magnetic resonance imaging (fMRI) is widely used to map patterns of brain
activation based on blood oxygenation level dependent (BOLD) signal changes associated …
activation based on blood oxygenation level dependent (BOLD) signal changes associated …
Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation
The cerebral cortex has a number of conserved morphological and functional characteristics
across brain regions and species. Among them, the laminar differences in microvascular …
across brain regions and species. Among them, the laminar differences in microvascular …
Laminar differences in functional oxygen metabolism in monkey visual cortex measured with calibrated fMRI
Y Bohraus, H Merkle, NK Logothetis, J Goense - Cell Reports, 2023 - cell.com
Blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI) of
cortical layers relies on the hemodynamic response and is biased toward large veins on the …
cortical layers relies on the hemodynamic response and is biased toward large veins on the …
New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brain
XH Zhu, N Zhang, Y Zhang… - Journal of Cerebral …, 2009 - journals.sagepub.com
The possible role of oxygen metabolism in supporting brain activation remains elusive. We
have used a newly developed neuroimaging approach based on high-field in vivo 17O …
have used a newly developed neuroimaging approach based on high-field in vivo 17O …
Calibrated fMRI for mapping absolute CMRO2: Practicalities and prospects
M Germuska, RG Wise - Neuroimage, 2019 - Elsevier
Functional magnetic resonance imaging (fMRI) is an essential workhorse of modern
neuroscience, providing valuable insight into the functional organisation of the brain. The …
neuroscience, providing valuable insight into the functional organisation of the brain. The …
Two-photon microscopy measurement of cerebral metabolic rate of oxygen using periarteriolar oxygen concentration gradients
S Sakadžić, MA Yaseen, R Jaswal… - …, 2016 - spiedigitallibrary.org
The cerebral metabolic rate of oxygen (CMRO 2) is an essential parameter for evaluating
brain function and pathophysiology. However, the currently available approaches for …
brain function and pathophysiology. However, the currently available approaches for …
MRI-based methods for quantification of the cerebral metabolic rate of oxygen
ZB Rodgers, JA Detre… - Journal of Cerebral Blood …, 2016 - journals.sagepub.com
The brain depends almost entirely on oxidative metabolism to meet its significant energy
requirements. As such, the cerebral metabolic rate of oxygen (CMRO2) represents a key …
requirements. As such, the cerebral metabolic rate of oxygen (CMRO2) represents a key …
[HTML][HTML] Assessing the repeatability of absolute CMRO2, OEF and haemodynamic measurements from calibrated fMRI
A Merola, MA Germuska, K Murphy, RG Wise - Neuroimage, 2018 - Elsevier
As energy metabolism in the brain is largely oxidative, the measurement of cerebral
metabolic rate of oxygen consumption (CMRO 2) is a desirable biomarker for quantifying …
metabolic rate of oxygen consumption (CMRO 2) is a desirable biomarker for quantifying …