RAS-related C3 botulinum toxin substrate 1 (Rac. 1) is one of the important members of Rho
GTPases. It is well known that Rac1 is a cytoskeleton regulation protein that regulates cell …

Small molecule inhibitors of GTPases are increasingly considered for the treatment of
multiple human pathologies. The GTPase Rac1 (Ras-related C3 botulinum toxin substrate 1) …

Cell migration is crucial for physiological and pathological processes such as
morphogenesis, wound repair, immune response and cancer invasion/metastasis. There are …

Ras-related C3 botulinum toxin substrate 1 (rac1) has been implicated in tumor epithelial–
mesenchymal transition (EMT); however, limited information is available regarding the role …

Three GTPases, RAC, RHO, and Cdc42, play essential roles in coordinating many cellular
functions during embryonic development, both in healthy cells and in disease conditions like …

Angiogenesis and metastasis are well recognized as processes fundamental to the
development of malignancy. Both processes involve the coordination of multiple cellular and …

Abstract A point mutation (P29S) in the RAS-related C3 botulinum toxin substrate 1 (RAC1)
was considered to be a trigger for melanoma, a form of skin cancer with highest mortality …

RAC1B is an alternatively spliced isoform of the monomeric GTPase RAC1. It differs from
RAC1 by a 19 amino acid in frame insertion, termed exon 3b, resulting in an accelerated …

Abstract Background Rho GTPases are involved in cellular functions relevant to cancer. The
roles of RhoA and Rac1 have already been established. However, the role of Rac3 in …

Colorectal adenocarcinoma is the second cause of cancer mortality in developed countries.
Rac1 is a member of the family of Rho GTPases that regulates many intracellular signaling …