[HTML][HTML] Age-related skeletal muscle dysfunction is aggravated by obesity: an investigation of contractile function, implications and treatment

J Tallis, S Shelley, H Degens, C Hill - Biomolecules, 2021 - mdpi.com
Obesity is a global epidemic and coupled with the unprecedented growth of the world's older
adult population, a growing number of individuals are both old and obese. Whilst both …

[HTML][HTML] Exploring the impact of obesity on skeletal muscle function in older age

PT Morgan, B Smeuninx, L Breen - Frontiers in Nutrition, 2020 - frontiersin.org
Sarcopenia is of important clinical relevance for loss of independence in older adults. The
prevalence of obesity in combination with sarcopenia ('sarcopenic-obesity') is increasing at …

Current perspectives on obesity and skeletal muscle contractile function in older adults

CR Straight, MJ Toth, MS Miller - Journal of Applied …, 2021 - journals.physiology.org
Obesity has become one of the most pressing public health issues of the 21st century and
currently affects a substantial proportion of the older adult population. Although the …

Skeletal muscle performance and ageing

M Tieland, I Trouwborst, BC Clark - Journal of cachexia …, 2018 - Wiley Online Library
The world population is ageing rapidly. As society ages, the incidence of physical limitations
is dramatically increasing, which reduces the quality of life and increases healthcare …

The clinical impact and biological mechanisms of skeletal muscle aging

Z Aversa, X Zhang, RA Fielding, I Lanza… - Bone, 2019 - Elsevier
Skeletal muscle is a highly plastic tissue that remarkably adapts to diverse stimuli including
exercise, injury, disuse, and, as discussed here, aging. Humans achieve peak skeletal …

The relationships between sarcopenic skeletal muscle loss during ageing and macronutrient metabolism, obesity and onset of diabetes

AA Welch, RPG Hayhoe, D Cameron - Proceedings of the Nutrition …, 2020 - cambridge.org
Skeletal muscle is integral to the metabolism and utilisation of macronutrients; however,
substantial muscle loss and morphological changes occur with ageing. These are …

Aging and muscle: a neuron's perspective

TM Manini, SL Hong, BC Clark - Current Opinion in Clinical …, 2013 - journals.lww.com
Recent evidence clearly indicates that muscle weakness associated with aging is not
entirely explained by classically postulated atrophy of muscle. In this issue, which focuses …

[HTML][HTML] Age-related changes in muscle architecture and metabolism in humans: the likely contribution of physical inactivity to age-related functional decline

NF Shur, L Creedon, S Skirrow, PJ Atherton… - Ageing Research …, 2021 - Elsevier
Abstract In the United Kingdom (UK), it is projected that by 2035 people aged> 65 years will
make up 23% of the population, with those aged> 85 years accounting for 5% of the total …

[HTML][HTML] Possible mechanisms linking obesity, steroidogenesis, and skeletal muscle dysfunction

AF Sheptulina, KY Antyukh, AR Kiselev… - Life, 2023 - mdpi.com
Increasing evidence suggests that skeletal muscles may play a role in the pathogenesis of
obesity and associated conditions due to their impact on insulin resistance and systemic …

Skeletal muscle function in the oldest-old: the role of intrinsic and extrinsic factors

M Venturelli, C Reggiani, RS Richardson… - Exercise and sport …, 2018 - journals.lww.com
In developed countries, one the fastest growing segments of the population comprises
people who are older than 85 yr and are currently considered the oldest-old. Unfortunately …