Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
Autophagy and disease
A Thorburn - Journal of biological chemistry, 2018 - ASBMB
As outlined in the accompanying Minireviews, autophagy is a complicated and highly
regulated process that delivers cellular material to lysosomes for degrading, recycling, and …
regulated process that delivers cellular material to lysosomes for degrading, recycling, and …
[HTML][HTML] Autophagy in the pathogenesis of disease
Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation,
development, and homeostasis. Autophagy principally serves an adaptive role to protect …
development, and homeostasis. Autophagy principally serves an adaptive role to protect …
Autophagy: a druggable process that is deregulated in aging and human disease
G Kroemer - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Autophagy (“self-eating”) constitutes one of the most spectacular yet subtly regulated
phenomena in cell biology. Similarly to cell division, differentiation, and death, autophagy is …
phenomena in cell biology. Similarly to cell division, differentiation, and death, autophagy is …
Autophagy—from molecular mechanisms to clinical relevance
M Lippai, Z Szatmári - Cell biology and toxicology, 2017 - Springer
Autophagy is a lysosomal degradation pathway of eukaryotic cells that is highly conserved
from yeast to mammals. During this process, cooperating protein complexes are recruited in …
from yeast to mammals. During this process, cooperating protein complexes are recruited in …
Autophagosome biogenesis and human health
T Kawabata, T Yoshimori - Cell discovery, 2020 - nature.com
Autophagy degrades the cytoplasmic contents engulfed by autophagosomes. Besides
providing energy and building blocks during starvation via random degradation, autophagy …
providing energy and building blocks during starvation via random degradation, autophagy …
Therapeutic modulation of autophagy: which disease comes first?
MC Maiuri, G Kroemer - Cell Death & Differentiation, 2019 - nature.com
The relentless efforts of thousands of researchers have allowed deciphering the molecular
machinery that regulates and executes autophagy, thus identifying multiple molecular …
machinery that regulates and executes autophagy, thus identifying multiple molecular …
Autophagy and disease: unanswered questions
Y Yang, DJ Klionsky - Cell Death & Differentiation, 2020 - nature.com
Autophagy is a process in which intracellular components and dysfunctional organelles are
delivered to the lysosome for degradation and recycling. Autophagy has various …
delivered to the lysosome for degradation and recycling. Autophagy has various …
Autophagy in disease: a double-edged sword with therapeutic potential
W Martinet, P Agostinis, B Vanhoecke… - Clinical …, 2009 - portlandpress.com
Autophagy is a catabolic trafficking pathway for bulk destruction and turnover of long-lived
proteins and organelles via regulated lysosomal degradation. In eukaryotic cells, autophagy …
proteins and organelles via regulated lysosomal degradation. In eukaryotic cells, autophagy …
Emerging role of selective autophagy in human diseases
K Mizumura, AMK Choi, SW Ryter - Frontiers in pharmacology, 2014 - frontiersin.org
Autophagy was originally described as a highly conserved system for the degradation of
cytosol through a lysosome-dependent pathway. In response to starvation, autophagy …
cytosol through a lysosome-dependent pathway. In response to starvation, autophagy …